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4/29/2021 4:10:06 AM | Browse: 52 | Download: 72
Publication Name World Journal of Gastroenterology
Manuscript ID 60827
Country/Territory China
2020-12-07 13:17
Peer-Review Started
2020-12-07 13:19
To Make the First Decision
Return for Revision
2021-01-10 18:46
2021-01-23 10:04
Second Decision
2021-03-09 09:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-10 18:33
Articles in Press
2021-03-10 18:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-04-15 15:14
Typeset the Manuscript
2021-04-27 01:34
Publish the Manuscript Online
2021-04-29 02:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis
Manuscript Source Unsolicited Manuscript
All Author List Xi-Hua Dong, Di Dai, Zhi-Dong Yang, Xiao-Ou Yu, Hua Li and Hui Kang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81871723
Corresponding Author Hui Kang, PhD, Professor, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. kanghui65@sina.com
Key Words S100 calcium binding protein A6; Long noncoding Ribonucleic acids; Primary biliary cholangitis; Biomarker; Diagnosis; Staging
Core Tip Primary biliary cholangitis (PBC) is an autoimmune liver disease which is characterized by intrahepatic cholestasis. Intrahepatic biliary epithelial cells were used as the research object. The expression of s100 calcium binding protein A6 (S100A6) was up-regulated in a bile duct ligation mouse model compared with sham mouse. Meanwhile, the relative expressions of plasma S100A6 messenger ribonucleic acid, LINC00472 and LINC01257 were up-regulated and the relative expression of LINC00312 was down-regulated in PBC patients. S100A6 and the three long noncoding ribonucleic acids can be used as biomarkers for PBC diagnosis and staging using receiver operating characteristic curve analysis. The results were further verified in vitro.
Publish Date 2021-04-29 02:12
Citation Dong XH, Dai D, Yang ZD, Yu XO, Li H, Kang H. S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis. World J Gastroenterol 2021; 27(17): 1973-1992
URL https://www.wjgnet.com/1007-9327/full/v27/i17/1973.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i17.1973
Full Article (PDF) WJG-27-1973.pdf
Full Article (Word) WJG-27-1973.docx
Manuscript File 60827_Auto_Edited_LM-Webster J-Clear.docx
Answering Reviewers 60827-Answering reviewers.pdf
Audio Core Tip 60827-Audio core tip.mp3
Biostatistics Review Certificate 60827-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 60827-Conflict-of-interest statement.pdf
Copyright License Agreement 60827-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60827-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 60827-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 60827-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60827-Language certificate.pdf
Peer-review Report 60827-Peer-review(s).pdf
Scientific Misconduct Check 60827-Scientific misconduct check.pdf
Scientific Editor Work List 60827-Scientific editor work list.pdf