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4/29/2021 4:10:06 AM | Browse: 491 | Download: 660
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Received |
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2020-12-07 13:17 |
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Peer-Review Started |
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2020-12-07 13:19 |
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2021-01-10 18:46 |
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Revised |
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2021-01-23 10:04 |
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Second Decision |
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2021-03-09 09:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-03-10 18:33 |
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Articles in Press |
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2021-03-10 18:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-15 15:14 |
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Typeset the Manuscript |
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2021-04-27 01:34 |
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Publish the Manuscript Online |
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2021-04-29 02:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Hua Dong, Di Dai, Zhi-Dong Yang, Xiao-Ou Yu, Hua Li and Hui Kang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81871723 |
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| Corresponding Author |
Hui Kang, PhD, Professor, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. kanghui65@sina.com |
| Key Words |
S100 calcium binding protein A6; Long noncoding Ribonucleic acids; Primary biliary cholangitis; Biomarker; Diagnosis; Staging |
| Core Tip |
Primary biliary cholangitis (PBC) is an autoimmune liver disease which is characterized by intrahepatic cholestasis. Intrahepatic biliary epithelial cells were used as the research object. The expression of s100 calcium binding protein A6 (S100A6) was up-regulated in a bile duct ligation mouse model compared with sham mouse. Meanwhile, the relative expressions of plasma S100A6 messenger ribonucleic acid, LINC00472 and LINC01257 were up-regulated and the relative expression of LINC00312 was down-regulated in PBC patients. S100A6 and the three long noncoding ribonucleic acids can be used as biomarkers for PBC diagnosis and staging using receiver operating characteristic curve analysis. The results were further verified in vitro. |
| Publish Date |
2021-04-29 02:12 |
| Citation |
Dong XH, Dai D, Yang ZD, Yu XO, Li H, Kang H. S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis. World J Gastroenterol 2021; 27(17): 1973-1992 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i17/1973.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i17.1973 |
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