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4/21/2021 8:05:01 AM | Browse: 421 | Download: 749
Publication Name World Journal of Gastroenterology
Manuscript ID 61129
Country/Territory China
Received
2020-12-22 11:56
Peer-Review Started
2020-12-22 11:58
To Make the First Decision
Return for Revision
2021-01-23 06:42
Revised
2021-02-04 10:16
Second Decision
2021-03-10 10:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-11 03:05
Articles in Press
2021-03-11 03:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-29 13:15
Typeset the Manuscript
2021-04-19 09:13
Publish the Manuscript Online
2021-04-21 05:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Depletion of MRPL35 inhibits the proliferation of gastric carcinoma by regulating downstream signaling protein
Manuscript Source Unsolicited Manuscript
All Author List Ling Yuan, Jia-Xin Li, Yi Yang, Yan Chen, Ting-Ting Ma, Shuang Liang, Yang Bu, Lei Yu and Yi Nan
Funding Agency and Grant Number
Funding Agency Grant Number
Ningxia Natural Science Foundation 2020AAC03130
Corresponding Author Yi Nan, MD, PhD, Professor, Key Laboratory of Hui Ethnic Medicine Modernization Ministry of Education, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn
Key Words Gastric carcinoma; MRPL35; Apoptosis; Proliferation; Tissue microarray; Isobaric tags for relative and absolute quantification
Core Tip MRPL35 is a member of the large subunit family of mitochondrial ribosomal protein. Our results showed that comparing with adjacent tissues, the expression of MRPL35 in gastric carcinoma (GC) tissues was increased significantly, which was related to age, lymph node metastasis, and the stage of pathological tumor node metastasis of GC patients. Knockdown of MRPL35 could inhibit GC cell proliferation, clone formation, tumor formation in BALB/c nude mice, induce apoptosis, reduce the expression of PICK1 and BCL-XL proteins, and increase that of AGR2 protein. These data indicated MRPL35 might be an oncogene and be used as a new therapeutic target for GC.
Publish Date 2021-04-21 05:56
Citation Yuan L, Li JX, Yang Y, Chen Y, Ma TT, Liang S, Bu Y, Yu L, Nan Y. Depletion of MRPL35 inhibits the proliferation of gastric carcinoma by regulating downstream signaling protein. World J Gastroenterol 2021; 27(16): 1785-1804
URL https://www.wjgnet.com/1007-9327/full/v27/i16/1785.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i16.1785
Full Article (PDF) WJG-27-1785.pdf
Full Article (Word) WJG-27-1785.docx
Manuscript File 61129_Auto_Edited_WangTQ.docx
Answering Reviewers 61129-Answering reviewers.pdf
Audio Core Tip 61129-Audio core tip.mp3
Biostatistics Review Certificate 61129-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61129-Conflict-of-interest statement.pdf
Copyright License Agreement 61129-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 61129-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 61129-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 61129-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61129-Language certificate.pdf
Supplementary Material 61129-Supplementary material.pdf
Peer-review Report 61129-Peer-review(s).pdf
Scientific Misconduct Check 61129-Scientific misconduct check.pdf
Scientific Editor Work List 61129-Scientific editor work list.pdf