| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Basic Study |
| Article Title |
Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ju-Wei Shao, Jin-De Wang, Qian He, Ying Yang, Ying-Ying Zou, Wei Su, Shu-Tian Xiang, Jian-Bo Li and Jing Fang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Endocrine Clinical Medical Center of Yunnan Province |
ZX2019‑02‑02 |
| Fund of the Diabetic Innovation Team in Yunnan Province |
2019HC002 |
| Special Joint Fund from Yunnan Provincial Department of Science and Technology and Kunming Medical University, Kunming, Yunnan, China. |
2018FE001(-267) |
| SKY Image Research Fund China |
Z-2014-07-2003-12 |
|
| Corresponding Author |
Jing Fang, MD, Professor, Institute for Health Sciences, Kunming Medical University, No. 1168 Chunrong West Road, Yuhua Street, Chenggong District, Kunming 650500, Yunnan Province, China. fangjing07@126.com |
| Key Words |
Diabetes-associated cognitive dysfunction; Diabetes mellitus; Type 2; Perfusion imaging; Receptors; Vascular endothelial growth factor; Hippocampus; Three-dimensional pseudo-continuous arterial spin labeling |
| Core Tip |
This study aimed to assess the correlation between cerebral blood flow (CBF) measured by 3D arterial spin labeling (3D-ASL), vascular endothelial growth factor (VEGF) expression, and diabetes-associated cognitive dysfunction (DACD) in a rat model of type 2 diabetes (T2DM). Our result showed low CBF in the hippocampus and decreased VEGF expression might be crucial in DACD. CBF measured on 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment associated with T2DM. This study would help in the early detection of DACD and guide treatment. |
| Publish Date |
2021-04-09 05:27 |
| Citation |
Shao JW, Wang JD, He Q, Yang Y, Zou YY, Su W, Xiang ST, Li JB, Fang J. Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat. World J Diabetes 2021; 12(4): 499-513 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i4/499.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i4.499 |
