Publication Name	World Journal of Diabetes
Manuscript ID	61668
Country	Taiwan

Received	2020-12-21 01:02
Peer-Review Started	2020-12-21 01:04
To Make the First Decision
Return for Revision	2021-01-07 07:26
Revised	2021-01-07 15:18
Second Decision	2021-01-15 07:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-22 03:40
Articles in Press	2021-01-22 03:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-02-08 05:26
Publish the Manuscript Online	2021-03-02 06:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Anti- and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
Manuscript Source	Invited Manuscript
All Author List	Chrong-Reen Wang and Hung-Wen Tsai
Funding Agency and Grant Number
Corresponding Author	Chrong-Reen Wang, MD, PhD, Professor, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138 Sheng-Li Road, Tainan 70403, Taiwan. wangcr@mail.ncku.edu.tw
Key Words	Insulin resistance; Diabetes mellitus; Tumor necrosis factor-α-targeted therapy; Non-tumor necrosis factor-α-targeted therapy; Rheumatoid arthritis; Psoriatic arthritis
Core Tip	The crucial mechanism leading to development of diabetes mellitus is the resistance of target cells to insulin, i.e. insulin resistance (IR), indicating the ineffective strength of signaling transduction from the receptor, downstream to the final substrates of insulin action. Autoimmune-mediated arthritis including rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, with the involvement of proinflammatory cytokines like tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β as their central pathogenesis, has been demonstrated to be associated with IR. Anti-TNF-α therapy, IL-1 blockade, IL-6 antagonist, Janus kinase inhibitor and phosphodiesterase type 4 blocker can reduce IR and improve diabetic hyperglycemia in autoimmune-mediated arthritis.
Publish Date	2021-03-02 06:51
Citation	Wang CR, Tsai HW. Anti- and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. World J Diabetes 2021; 12(3): 238-260
URL	https://www.wjgnet.com/1948-9358/full/v12/i3/238.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i3.238

Full Article (PDF)	WJD-12-238.pdf
Full Article (Word)	WJD-12-238.docx
Manuscript File	61668_Auto_Edited_LM.docx
Answering Reviewers	61668-Answering reviewers.pdf
Audio Core Tip	61668-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	61668-Conflict-of-interest statement.pdf
Copyright License Agreement	61668-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	61668-Language certificate.pdf
Peer-review Report	61668-Peer-review(s).pdf
Scientific Misconduct Check	61668-Bing-Ma YJ-1.jpg
Scientific Misconduct Check	61668-Bing-Fan JR-2.png
Scientific Misconduct Check	61668-Scientific misconduct check.pdf
Scientific Editor Work List	61668-Scientific editor work list.pdf