Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	61779
Country	Türkiye

Received	2020-12-18 09:07
Peer-Review Started	2020-12-18 09:08
To Make the First Decision
Return for Revision	2021-01-10 18:33
Revised	2021-01-10 19:52
Second Decision	2021-03-09 08:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-10 18:50
Articles in Press	2021-03-10 18:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-18 02:28
Publish the Manuscript Online	2021-03-18 08:34

ISSN	2150-5349 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	Bahri Abayli, Cansu Abaylı and Genco Gencdal
Funding Agency and Grant Number
Corresponding Author	Genco Gencdal, MD, Associate Professor, Department of Gastroenterology, Hepatology and Liver Transplantation, Koc University, School of Medicine, özel GOP hastanesi endoskopi birimi gop istanbul, İstanbul 34300, Türkiye. gencogencdal@yahoo.co.uk
Key Words	Hepatitis B; Tenofovir; Chronic hepatitis; Biopsy; Liver; Fibrosis
Core Tip	Hepatitis B virus is a universal health problem. There are approximately 250 million people living with hepatitis B worldwide, and approximately 600000 of these people die every year due to the virus. Viral suppression with treatment can also lead to histological healing. Recent studies have found histological improvements in sexually transmitted disease patients who received antiviral therapy. In the current study, we aimed to compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen-negative chronic hepatitis B who have been receiving tenofovir disoproxil fumarate (TDF) treatment at our clinic for at least 5 years. A total of 50 hepatitis be antigen-negative chronic hepatitis B patients were included in the study (mean age: 47.9 ± 10.4 years, men: 27.54%). Histological improvement was observed in 78% (39) of the patients after 5 years of treatment. After the 5 years of treatment, the mean Ishak score of the patients was 1.3 ± 1.3, and the mean histologic activity index score was 4.1 ± 2.8. A 1.53 point reduction in Ishak fibrosis score was detected after long-term TDF treatment. Liver biopsies after 5 years of TDF treatment revealed a significant histological response and a regression of the necroinflammatory score compared to pretreatment liver biopsies.
Publish Date	2021-03-18 08:34
Citation	Abayli B, Abaylı C, Gencdal G. Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B. World J Gastrointest Pharmacol Ther 2021; 12(2): 32-39
URL	https://www.wjgnet.com/2150-5349/full/v12/i2/32.htm
DOI	https://dx.doi.org/10.4292/wjgpt.v12.i2.32

Full Article (PDF)	WJGPT-12-32.pdf
Full Article (Word)	WJGPT-12-32.docx
Manuscript File	61779_Auto_Edited_LM.docx
Answering Reviewers	61779-Answering reviewers.pdf
Audio Core Tip	61779-Audio core tip.mp3
Biostatistics Review Certificate	61779-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	61779-Conflict-of-interest statement.pdf
Copyright License Agreement	61779-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	61779-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	61779-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	61779-Language certificate.pdf
Peer-review Report	61779-Peer-review(s).pdf
Scientific Misconduct Check	61779-Scientific misconduct check.pdf
Scientific Editor Work List	61779-Scientific editor work list.pdf