Publication Name	World Journal of Clinical Cases
Manuscript ID	61852
Country	China

Received	2020-12-21 02:15
Peer-Review Started	2020-12-21 02:16
To Make the First Decision
Return for Revision	2021-01-17 06:21
Revised	2021-01-26 01:43
Second Decision	2021-03-09 13:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-10 19:50
Articles in Press	2021-03-10 19:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-18 02:40
Typeset the Manuscript	2021-04-16 07:41
Publish the Manuscript Online	2021-04-29 08:35

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Rehabilitation
Manuscript Type	Minireviews
Article Title	Non-invasive physical therapy as salvage measure for ischemic skin flap: A literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Yin-Hua Zheng, Li-Quan Yin, Hai-Kun Xu and Xu Gong
Funding Agency and Grant Number
Corresponding Author	Xu Gong, MD, Doctor, Department of Hand and Foot Surgery, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. gongxu@jlu.edu.cn
Key Words	Physiotherapy; Skin flap; Hyperbaric oxygen; Electrical stimulation therapy; Heat stress pretreatment; Phototherapy; Vibration therapy
Core Tip	In this study, the molecular mechanism of physical therapy [such as vascular endothelial growth factor, heat shock protein (HSP) 32 and HSP70] was closely linked with the actual clinical application to study the effect of non-invasive physical therapy on ischemic flaps. Its effect of promoting vasodilation and regeneration as well as inhibiting cell apoptosis is also applicable to peripheral vascular lesions caused by diabetes and wound healing. The close connection between molecules and practical applications is conducive to the selection of the right physical therapy methods and parameters, to achieve targeted therapy, shorten the treatment time, and quickly alleviate the pain of patients.
Publish Date	2021-04-29 08:35
Citation	Zheng YH, Yin LQ, Xu HK, Gong X. Non-invasive physical therapy as salvage measure for ischemic skin flap: A literature review. World J Clin Cases 2021; 9(14): 3227-3237
URL	https://www.wjgnet.com/2307-8960/full/v9/i14/3227.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i14.3227

Full Article (PDF)	WJCC-9-3227.pdf
Full Article (Word)	WJCC-9-3227.docx
Manuscript File	61852-Review-FilipodiaCL.docx
Answering Reviewers	61852-Answering reviewers.pdf
Audio Core Tip	61852-Audio Core Tip.m4a
Conflict-of-Interest Disclosure Form	61852-Conflict-of-interest statement.pdf
Copyright License Agreement	61852-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	61852-Language certificate.pdf
Peer-review Report	61852-Peer-review(s).pdf
Scientific Misconduct Check	61852-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61852-Bing-Fan JR-2.png
Scientific Misconduct Check	61852-Scientific misconduct check.pdf
Scientific Editor Work List	61852-Scientific editor work list.pdf