5/10/2021 8:19:21 AM | Browse: 468 | Download: 679
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 61970 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||
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| Manuscript Type | Basic Study | ||||||||||
| Article Title | Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells | ||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||
| All Author List | Xiao-Xin Zhang, Hao-Yang Wang, Xue-Fei Yang, Zi-Qi Lin, Na Shi, Chan-Juan Chen, Lin-Bo Yao, Xin-Min Yang, Jia Guo, Qing Xia and Ping Xue | ||||||||||
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| Corresponding Author | Ping Xue, MD, PhD, Professor, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. xueping@wchscu.cn | ||||||||||
| Key Words | Acute pancreatitis; Acute lung injury; Pulmonary microvascular endothelial cells; P38; SB203580; Apoptosis | ||||||||||
| Core Tip | In this study, we explored the role of the p38 MAPK pathway in the TNF-α-induced inflammation and apoptosis of pulmonary microvascular endothelial cell (PMVEC) in vitro and verified the effect of SB203580-mediated p38 inhibition on severe acute pancreatitis-related acute lung injury (SAP-ALI) in rats. We found that p38 MAPK overactivation promoted TNF-α-induced inflammatory cytokine expression and PMVECs apoptosis in vitro. Furthermore, SB203580 improved SAP-ALI by downregulating the levels of p-p38, NFκB, p-SATA3 and Myd88 in the lung. On the other side, it upregulated the IκB and HO-1 Levels in the lungs, which alleviated inflammation and apoptotic cell death in rats. | ||||||||||
| Publish Date | 2021-05-10 07:46 | ||||||||||
| Citation | Zhang XX, Wang HY, Yang XF, Lin ZQ, Shi N, Chen CJ, Yao LB, Yang XM, Guo J, Xia Q, Xue P. Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells. World J Gastroenterol 2021; 27(18): 2141-2159 | ||||||||||
| URL | https://www.wjgnet.com/1007-9327/full/v27/i18/2141.htm | ||||||||||
| DOI | https://dx.doi.org/10.3748/wjg.v27.i18.2141 |
| Full Article (PDF) | WJG-27-2141.pdf |
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| Full Article (Word) | WJG-27-2141.docx |
| The ARRIVE Guidelines | 61970-The-ARRIVE-Guidelines-revision.pdf |
| Manuscript File | 61970-Review-FilipodiaCL.docx |
| Answering Reviewers | 61970-Answering reviewers.pdf |
| Audio Core Tip | 61970-Audio core tip.mp3 |
| Biostatistics Review Certificate | 61970-Biostatistics statement.pdf |
| Conflict-of-Interest Disclosure Form | 61970-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 61970-Copyright license agreement.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 61970-Grant application form(s).pdf |
| Institutional Animal Care and Use Committee Approval Form or Document | 61970-Institutional animal care and use committee statement.pdf |
| Non-Native Speakers of English Editing Certificate | 61970-Language certificate.pdf |
| Peer-review Report | 61970-Peer-review(s).pdf |
| Scientific Misconduct Check | 61970-Bing-Wang JL-1.jpg |
| Scientific Misconduct Check | 61970-Scientific misconduct check.pdf |
| Scientific Editor Work List | 61970-Scientific editor work list.pdf |
| CrossCheck Report | 61970-CrossCheck report.pdf |