| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Xin Zhang, Hao-Yang Wang, Xue-Fei Yang, Zi-Qi Lin, Na Shi, Chan-Juan Chen, Lin-Bo Yao, Xin-Min Yang, Jia Guo, Qing Xia and Ping Xue |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81873107 |
| National Natural Science Foundation of China |
82004154 |
| National Natural Science Foundation of China |
81573766 |
| Science and Technology Planning Program of Sichuan |
2019YFS0259 |
|
| Corresponding Author |
Ping Xue, MD, PhD, Professor, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China. xueping@wchscu.cn |
| Key Words |
Acute pancreatitis; Acute lung injury; Pulmonary microvascular endothelial cells; P38; SB203580; Apoptosis |
| Core Tip |
In this study, we explored the role of the p38 MAPK pathway in the TNF-α-induced inflammation and apoptosis of pulmonary microvascular endothelial cell (PMVEC) in vitro and verified the effect of SB203580-mediated p38 inhibition on severe acute pancreatitis-related acute lung injury (SAP-ALI) in rats. We found that p38 MAPK overactivation promoted TNF-α-induced inflammatory cytokine expression and PMVECs apoptosis in vitro. Furthermore, SB203580 improved SAP-ALI by downregulating the levels of p-p38, NFκB, p-SATA3 and Myd88 in the lung. On the other side, it upregulated the IκB and HO-1 Levels in the lungs, which alleviated inflammation and apoptotic cell death in rats. |
| Publish Date |
2021-05-10 07:46 |
| Citation |
Zhang XX, Wang HY, Yang XF, Lin ZQ, Shi N, Chen CJ, Yao LB, Yang XM, Guo J, Xia Q, Xue P. Alleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells. World J Gastroenterol 2021; 27(18): 2141-2159 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i18/2141.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i18.2141 |
