Publication Name	World Journal of Meta-Analysis
Manuscript ID	62050
Country	France

Received	2020-12-27 12:27
Peer-Review Started	2020-12-27 12:28
To Make the First Decision
Return for Revision	2021-01-30 10:40
Revised	2021-01-30 12:32
Second Decision	2021-02-24 06:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-02-24 21:09
Articles in Press	2021-02-24 21:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-02-26 09:11
Publish the Manuscript Online	2021-03-02 12:30

ISSN	2308-3840 (online)
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Category	Medical Ethics
Manuscript Type	Minireviews
Article Title	Should we use full analgesic dose of opioids for organ procurement in brainstem dead?
Manuscript Source	Invited Manuscript
All Author List	Philippe Charlier, John-David Rebibo and Nadia Benmoussa
Funding Agency and Grant Number
Corresponding Author	Philippe Charlier, DPhil, MD, PhD, Assistant Professor, Director, Director, Laboratory Anthropology, Archaeology, Biology (LAAB), Paris-Saclay University, 2 avenue de la Source de la Bièvre, Montigny-Le-Bretonneux 78180, France. philippe.charlier@uvsq.fr
Key Words	Bioethics; Transplantation; Anaesthesiology; Brainstem dead
Core Tip	Families facing the growing demand for organ removal from their loved ones are questioning the possible suffering of the brainstem dead patient. A frequent question they ask to coordinating doctors is: are you sure he will not feel anything? Currently due to the risk of exacerbation of spinal reflexes and abnormal movements following surgical stimuli, it is recommended to use a curarization and an analgesic agent (most often morphine). The doses of opioids are less important than during usual anaesthesia, whereas the person is considered brainstem dead and there is no longer any cerebral integration of the pain. But what assures us that absolutely no more sensibility exists at this precise moment? We propose that further neuroscientific analyses be conducted in order to improve our knowledge about such a sensibility. We ask to the medical community if we should rather use full analgesic dose of opioids, and question if this would make the levies more "ethical"?
Publish Date	2021-03-02 12:30
Citation	Charlier P, Rebibo JD, Benmoussa N. Should we use full analgesic dose of opioids for organ procurement in brainstem dead? World J Meta-Anal 2021; 9(1): 51-53
URL	https://www.wjgnet.com/2308-3840/full/v9/i1/51.htm
DOI	https://dx.doi.org/10.13105/wjma.v9.i1.51

Full Article (PDF)	WJMA-9-51.pdf
Full Article (Word)	WJMA-9-51.docx
Manuscript File	62050_Auto_Edited.docx
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Audio Core Tip	62050-Audio core tip.m4a
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Peer-review Report	62050-Peer-review(s).pdf
Scientific Misconduct Check	62050-Scientific misconduct check.pdf
Scientific Editor Work List	62050-Scientific editor work list.pdf
CrossCheck Report	62050-CrossCheck report.pdf