Publication Name	World Journal of Gastroenterology
Manuscript ID	62457
Country	Germany

Received	2021-01-09 10:51
Peer-Review Started	2021-01-09 10:52
To Make the First Decision
Return for Revision	2021-01-23 03:45
Revised	2021-03-10 14:55
Second Decision	2021-06-04 08:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-04 10:08
Articles in Press	2021-06-04 10:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-18 03:27
Publish the Manuscript Online	2021-06-25 09:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Retrospective Study
Article Title	Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience
Manuscript Source	Invited Manuscript
All Author List	Oliver Schwandner
Funding Agency and Grant Number
Corresponding Author	Oliver Schwandner, FASCRS, MD, Professor, Department of Proctology, Krankenhaus Barmherzige Brueder, Pruefeninger Str 86, Regensburg 93049, Germany. oliver.schwandner@barmherzige-regensburg.de
Key Words	Complex anal fistula; Crohn’s disease; Stem cell therapy; Mesenchymal stem cells; Darvadstrocel; Treatment; Surgery; Outcomes
Core Tip	This is a retrospective single-center study on the application of allogenic, adipose-derived mesenchymal stem cells (darvadstrocel) for complex perianal fistula associated with Crohn’s disease, providing structured inclusion and exclusion criteria for 12 patients. The current data demonstrate that the management by local stem cell therapy is safe and effective. However, based on the small patient sample size and the retrospective analysis of routine clinical data, a general conclusion remains limited. Therefore, further prospective controlled studies are mandatory to assess the definite role of adipose-derived mesenchymal stem cells for complex anal fistula in Crohn’s disease.
Publish Date	2021-06-25 09:46
Citation	Schwandner O. Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience. World J Gastroenterol 2021; 27(24): 3643-3653
URL	https://www.wjgnet.com/1007-9327/full/v27/i24/3643.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i24.3643

Full Article (PDF)	WJG-27-3643.pdf
Full Article (Word)	WJG-27-3643.docx
Manuscript File	62457_Auto_Edited-JPY.docx
Answering Reviewers	62457-Answering reviewers.pdf
Audio Core Tip	62457-Audio core tip.m4a
Biostatistics Review Certificate	62457-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	62457-Conflict-of-interest statement.pdf
Copyright License Agreement	62457-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	62457-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	62457-Language certificate.pdf
Peer-review Report	62457-Peer-review(s).pdf
Scientific Misconduct Check	62457-Bing-Wang JL-1.jpg
Scientific Misconduct Check	62457-Bing-Fan JR-2.png
Scientific Misconduct Check	62457-Scientific misconduct check.pdf
Scientific Editor Work List	62457-Scientific editor work list.pdf
CrossCheck Report	62457-CrossCheck report.pdf
CrossCheck Report	62457-CrossCheck.png