| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Hua Li, Yong-Yi Huang, Lin-Ming Lu, Li-Juan Zhao, Xian-Ke Luo, Ru-Jia Li, Yuan-Yuan Dai, Chun Qin, Yan-Qiang Huang and Hao Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81760739 |
| National Natural Science Foundation of China |
31460023 |
| Special Fund Projects for Guiding Local Science and Technology Development by the Chinese Government |
GUIKEZY20198004 |
|
| Corresponding Author |
Yan-Qiang Huang, MD, PhD, Professor, Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, No. 98 Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com |
| Key Words |
Helicobacter pylori; Clarithromycin-resistance; Diagnosis gene; Early genetic diagnosis; Helicobacter pylori strains |
| Core Tip |
The World Health Organization designated clarithromycin-resistant Helicobacter pylori a high priority among bacteria for antibiotic research and development, but the clarithromycin-resistant mechanism remains unclear. We isolated and cultured clinical Helicobacter pylori strains, determined their minimal inhibitory concentrations, completed genome sequencing of hp1181 and hp1184 genes, their mutations, etc., and found the expressions of the genes hp1184 and hp1181 were associated with clarithromycin resistance, so they can be used as genes for early diagnosis. This research may prove useful in the diagnosis, prevention, and treatment of clarithromycin-resistant Helicobacter pylori. |
| Publish Date |
2021-06-25 09:46 |
| Citation |
Li XH, Huang YY, Lu LM, Zhao LJ, Luo XK, Li RJ, Dai YY, Qin C, Huang YQ, Chen H. Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori. World J Gastroenterol 2021; 27(24): 3595-3608 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i24/3595.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i24.3595 |
