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4/29/2021 4:10:06 AM | Browse: 41 | Download: 59
Publication Name World Journal of Gastroenterology
Manuscript ID 62997
Country/Territory Brazil
Received
2021-01-22 14:36
Peer-Review Started
2021-01-22 14:40
To Make the First Decision
Return for Revision
2021-02-28 02:44
Revised
2021-03-13 13:43
Second Decision
2021-04-07 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-07 20:42
Articles in Press
2021-04-07 20:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-04-15 00:47
Publish the Manuscript Online
2021-04-29 02:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Repurposing metformin for the treatment of gastrointestinal cancer
Manuscript Source Invited Manuscript
All Author List Ademar Dantas Cunha Júnior, Arinilda Campos Bragagnoli, Felipe Osório Costa and José Barreto Campello Carvalheira
Funding Agency and Grant Number
Corresponding Author José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Department of Internal Medicine, Division of Oncology, University of Campinas (UNICAMP), Tessália Vieira Camargo, S/N, Campinas 13083-970, São Paulo, Brazil. jbcc@unicamp.br
Key Words Antidiabetic treatments; Gastrointestinal tumors; Therapeutic target
Core Tip Modulation of cell function into the neoplastic and around the microenvironment tissue are possible cancer targets utilized by metformin to raise chemotherapy's anti-tumor outcomes. Herein we review the studies that have demonstrated the likelihood of metformin as chemo and radiosensitizer, in addition to its chemopreventive and direct therapeutic activity in gastrointestinal tumors.
Publish Date 2021-04-29 02:12
Citation Cunha Júnior AD, Bragagnoli AC, Costa FO, Carvalheira JBC. Repurposing metformin for the treatment of gastrointestinal cancer. World J Gastroenterol 2021; 27(17): 1883-1904
URL https://www.wjgnet.com/1007-9327/full/v27/i17/1883.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i17.1883
Full Article (PDF) WJG-27-1883.pdf
Full Article (Word) WJG-27-1883.docx
Manuscript File 62997_Auto_Edited_LM.docx
Answering Reviewers 62997-Answering reviewers.pdf
Audio Core Tip 62997-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 62997-Conflict-of-interest statement.pdf
Copyright License Agreement 62997-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 62997-Language certificate.pdf
Peer-review Report 62997-Peer-review(s).pdf
Scientific Misconduct Check 62997-Bing-Fan JR-2.png
Scientific Misconduct Check 62997-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 62997-Scientific misconduct check.pdf
Scientific Editor Work List 62997-Scientific editor work list.pdf