Publication Name	World Journal of Gastroenterology
Manuscript ID	63044
Country	United Kingdom

Received	2021-01-23 13:34
Peer-Review Started	2021-01-23 13:39
To Make the First Decision
Return for Revision	2021-02-10 05:40
Revised	2021-02-10 12:53
Second Decision	2021-03-11 13:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-12 00:41
Articles in Press	2021-03-12 00:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-22 03:24
Publish the Manuscript Online	2021-03-30 07:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Metabolic complications of hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Rahul Chaudhari, Sherouk Fouda, Ashik Sainu and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, Consultant Physician-Scientist, Honorary Research Fellow, Senior Researcher, Department of Endocrinology and Metabolism , Lancashire Teaching Hospitals NHS Trust, Royal Preston Hospital, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Key Words	Chronic hepatitis C infection; Insulin resistance; Metabolic syndrome; Cardiovascular diseases; Fatty liver; Diabetes mellitus
Core Tip	Available evidence proves a strong association between hepatitis C virus (HCV) and metabolic complications such as hyperlipidemia, hepatic steatosis, insulin resistance, metabolic syndrome, and diabetes mellitus. De novo development of insulin resistance and hepatic steatosis in chronic HCV infection influences the disease progression in the liver and enhances overall morbidity and mortality. The influence of metabolic diseases on HCV infection can increase disease severity. The interplay between HCV major proteins and the liver-muscle-adipose axis is complex and still not fully elucidated. Coexistence of metabolic diseases such as diabetes mellitus and HCV infection are also known to result in adverse outcomes of both disorders. There is evidence that successful treatment halts the progression of liver disease, but more studies are required on how treatment influences the metabolic manifestations.
Publish Date	2021-03-30 07:03
Citation	Chaudhari R, Fouda S, Sainu A, Pappachan JM. Metabolic complications of hepatitis C virus infection. World J Gastroenterol 2021; 27(13): 1267-1282
URL	https://www.wjgnet.com/1007-9327/full/v27/i13/1267.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i13.1267

Full Article (PDF)	WJG-27-1267.pdf
Full Article (Word)	WJG-27-1267.docx
Manuscript File	63044_Auto_Edited.docx
Answering Reviewers	63044-Answering reviewers.pdf
Audio Core Tip	63044-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63044-Conflict-of-interest statement.pdf
Copyright License Agreement	63044-Copyright license agreement.pdf
Peer-review Report	63044-Peer-review(s).pdf
Scientific Misconduct Check	63044-Bing-Wang JL-1.jpg
Scientific Misconduct Check	63044-Scientific misconduct check.pdf
Scientific Editor Work List	63044-Scientific editor work list.pdf