Publication Name	World Journal of Gastroenterology
Manuscript ID	63339
Country	China

Received	2021-02-25 09:54
Peer-Review Started	2021-02-25 09:54
To Make the First Decision
Return for Revision	2021-04-18 03:10
Revised	2021-04-27 01:43
Second Decision	2021-05-27 07:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-27 09:41
Articles in Press	2021-05-27 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-10 01:25
Typeset the Manuscript	2021-07-07 01:39
Publish the Manuscript Online	2021-07-12 00:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xiu-Yan Li, Qing-Xia Guan, Yu-Zhou Shang, Yan-Hong Wang, Shao-Wa Lv, Zhi-Xin Yang, Rui Wang, Yu-Fei Feng, Wei-Nan Li and Yong-Ji Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82074025 National Natural Science Foundation of China 82074271 the Heilongjiang Traditional Chinese Medicine Research Project ZHY18-047 Scientific Research Project of Heilongjiang Health Committee 2020-293
Corresponding Author	Yong-Ji Li, PhD, Professor, College of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang Province, China. liyongji2009@163.com
Key Words	Norcantharidin; Metal-organic frameworks; IRMOF-3; Temperature-sensitive gel; Drug delivery; Liver cancer
Core Tip	Norcantharidin (NCTD) is suitable for the treatment of primary liver cancer, especially early and middle primary liver cancer. However, the side effects of NCTD have limited its application. Therefore, we aimed to establish a liver-targeting therapy in which NCTD is loaded into IRMOF-3 coated with a thermosensitive gel, which can be efficiently delivered to liver cancer cells and slowly released. The results reveal that this thermosensitive gel-encapsulated IRMOF-3 has great advantages as an antitumor drug carrier and provides some ideas for passive targeting therapy of tumors.
Publish Date	2021-07-12 00:42
Citation	Li XY, Guan QX, Shang YZ, Wang YH, Lv SW, Yang ZX, Wang R, Feng YF, Li WN, Li YJ. Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer. World J Gastroenterol 2021; 27(26): 4208-4220
URL	https://www.wjgnet.com/1007-9327/full/v27/i26/4208.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i26.4208

Full Article (PDF)	WJG-27-4208.pdf
Full Article (Word)	WJG-27-4208.docx
Manuscript File	63339-Review-FilipodiaCL.docx
Answering Reviewers	63339-Answering reviewers.pdf
Audio Core Tip	63339-Audio core tip.m4a
Biostatistics Review Certificate	63339-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	63339-Conflict-of-interest statement.pdf
Copyright License Agreement	63339-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63339-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	63339-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	63339-Language certificate.pdf
Peer-review Report	63339-Peer-review(s).pdf
Scientific Misconduct Check	63339-Bing-Wang JL-1.jpg
Scientific Misconduct Check	63339-Bing-Gong ZM-2.png
Scientific Misconduct Check	63339-CrossCheck.png
Scientific Misconduct Check	63339-Scientific misconduct check.pdf
Scientific Editor Work List	63339-Scientific editor work list.pdf
CrossCheck Report	63339-CrossCheck report.pdf