Publication Name	World Journal of Gastroenterology
Manuscript ID	63387
Country	Greece

Received	2021-01-28 07:10
Peer-Review Started	2021-01-28 07:13
To Make the First Decision
Return for Revision	2021-03-29 03:13
Revised	2021-04-12 20:07
Second Decision	2021-06-18 09:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-18 11:35
Articles in Press	2021-06-18 11:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-25 04:47
Typeset the Manuscript	2021-07-15 08:15
Publish the Manuscript Online	2021-07-19 14:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Update on the association of hepatitis B and intrahepatic cholangiocarcinoma: Is there new evidence?
Manuscript Source	Invited Manuscript
All Author List	Nikolaos Fragkou, Lazaros Sideras, Panteleimon Panas, Christos Emmanouilides and Emmanouil Sinakos
Funding Agency and Grant Number
Corresponding Author	Emmanouil Sinakos, MD, PhD, Assistant Professor, Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Konstantinopoleos 49, Thessaloniki 54642, Greece. em_sinakos@yahoo.com
Key Words	Cholangiocarcinoma; Hepatitis B; Intrahepatic; Hepatocellular carcinoma; Resection; Chemotherapy
Core Tip	Cholangiocarcinoma (CCA) is the second most frequent primary liver cancer. Intrahepatic CCA (iCCA), a subgroup of CCA, has a pronounced association with hepatitis B virus (HBV) infection. Recent data have strengthened this association both in terms of epidemiology and pathogenesis. Moreover, the potential for the development of the combined hepatocellular-cholangiocarcinoma form poses additional difficulties in the successful management of iCCA. We herein discuss the available epidemiological data, present the current knowledge on the pathogenesis of HBV-associated iCCA and review all the available information for the diagnosis and management of this aggressive cancer.
Publish Date	2021-07-19 14:10
Citation	Fragkou N, Sideras L, Panas P, Emmanouilides C, Sinakos E. Update on the association of Hepatitis B and intrahepatic cholangiocarcinoma: Is there new evidence? World J Gastroenterol 2021; 27(27): 4252-4275
URL	https://www.wjgnet.com/1007-9327/full/v27/i27/4252.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i27.4252

Full Article (PDF)	WJG-27-4252.pdf
Full Article (Word)	WJG-27-4252.docx
Manuscript File	63387-Review-FilipodiaCL (Over 9,000).docx
Answering Reviewers	63387-Answering reviewers.pdf
Audio Core Tip	63387-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63387-Conflict-of-interest statement.pdf
Copyright License Agreement	63387-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63387-Language certificate.pdf
Peer-review Report	63387-Peer-review(s).pdf
Scientific Misconduct Check	63387-Bing-Ma YJ-1.jpg
Scientific Misconduct Check	63387-Bing-Fan JR-2.png
Scientific Misconduct Check	63387-Scientific misconduct check.pdf
Scientific Editor Work List	63387-Scientific editor work list.pdf