Publication Name	World Journal of Gastroenterology
Manuscript ID	63526
Country	Hungary

Received	2021-02-04 15:41
Peer-Review Started	2021-01-29 02:40
To Make the First Decision
Return for Revision	2021-03-06 04:47
Revised	2021-03-19 18:25
Second Decision	2021-05-20 13:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-20 14:15
Articles in Press	2021-05-20 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-15 07:19
Publish the Manuscript Online	2021-06-18 05:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	COVID-19-associated diarrhea
Manuscript Source	Invited Manuscript
All Author List	Klara Megyeri, Áron Dernovics, Zaid I I Al-Luhaibi and András Rosztóczy
Funding Agency and Grant Number	Funding Agency Grant Number Stipendium Hungaricum Program 109162
Corresponding Author	Klara Megyeri, MD, PhD, Associate Professor, Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, Szeged 6720, Csongrad, Hungary. megyeri.klara@med.u-szeged.hu
Key Words	COVID-19; Diarrhea; Ionic imbalance; Viroporin; Angiotensin-converting enzyme type 2; Leaky gut
Core Tip	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in enterocytes, triggers ionic imbalances, activates the NLRP3 inflammasome pathway, induces apoptosis, and exerts a dual effect on the autophagic process. These effects of SARS-CoV-2 lead to the development of leaky gut. Increased permeability triggers the absorption of lipopolysaccharide into the circulation, further exacerbating inflammation induced by viral infection. In addition to drugs that affect the inflammatory response and viral replication, agents targeting autophagy and apoptosis appear to be potentially suitable for the treatment of coronavirus disease 2019 (COVID-19). The fecal-oral route of SARS-CoV-2 transmission calls for strict and more consistent adherence to hygiene rules to prevent the spread of COVID-19.
Publish Date	2021-06-18 05:06
Citation	Megyeri K, Dernovics Á, Al-Luhaibi ZII, Rosztóczy A. COVID-19-associated diarrhea. World J Gastroenterol 2021; 27(23): 3208-3222
URL	https://www.wjgnet.com/1007-9327/full/v27/i23/3208.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i23.3208

Full Article (PDF)	WJG-27-3208.pdf
Full Article (Word)	WJG-27-3208.docx
Manuscript File	63526_Auto_Edited-ZMG.docx
Answering Reviewers	63526-Answering reviewers.pdf
Audio Core Tip	63526-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63526-Conflict-of-interest statement.pdf
Copyright License Agreement	63526-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63526-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	63526-Language certificate.pdf
Peer-review Report	63526-Peer-review(s).pdf
Scientific Misconduct Check	63526-Bing-Wang JL-1.jpg
Scientific Misconduct Check	63526-Scientific misconduct check.pdf
Scientific Editor Work List	63526-Scientific editor work list.pdf
CrossCheck Report	63526-CrossCheck report.pdf