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10/15/2021 9:59:38 AM | Browse: 422 | Download: 1232
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Received |
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2021-01-29 04:38 |
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Peer-Review Started |
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2021-01-29 04:43 |
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First Decision by Editorial Office Director |
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2021-05-02 00:37 |
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Return for Revision |
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2021-05-04 09:07 |
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Revised |
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2021-05-20 00:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-08 03:00 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-08 10:30 |
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Articles in Press |
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2021-09-08 10:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-11 08:00 |
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Publish the Manuscript Online |
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2021-10-15 09:45 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Diana Ronderos, Alaa Mabrouk Salem Omar, Hafsa Abbas, Jasbir Makker, Ahmed Baiomi, Haozhe Sun, Nikhitha Mantri, YongsuN Choi, Ked Fortuzi, Dongmin Shin, Harish Patel and Sridhar Chilimuri |
| Funding Agency and Grant Number |
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| Corresponding Author |
Sridhar Chilimuri, MD, Chairman, Department of Internal Medicine, BronxCare Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, United States. chilimuri@bronxcare.org |
| Key Words |
Hepatitis C; Acute liver injury; Seropositive; COVID-19; Mortality |
| Core Tip |
In patients with coronavirus disease 2019 (COVID-19), history of hepatitis C infection accentuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) viral virulence and is a strong predictor of in-hospital mortality irrespective of baseline comorbidities, laboratory parameters, or COVID-19-induced liver injury. History of hepatitis C infection (HCV) in these patients seems to add a cumulative mortality risk to any clinical or laboratory profile. The mechanisms involved may be related to extra hepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 virus and subsequent endothelial dysfunction. The realization is important for better characterization of the disease and triage this sub-group as high risk for therapeutic or prophylactic measures like vaccines. |
| Publish Date |
2021-10-15 09:45 |
| Citation |
Ronderos D, Omar AMS, Abbas H, Makker J, Baiomi A, Sun H, Mantri N, Choi Y, Fortuzi K, Shin D, Patel H, Chilimuri S. Chronic and Seropositive Hepatitis C Infection in COVID-19 patients is Associated with In-Hospital Mortality Independent of Baseline Comorbidities and Liver Injury. World J Clin Cases 2021; 9(29): 8749-8762 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i29/8749.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i29.8749 |
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