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6/7/2021 12:50:08 PM | Browse: 27 | Download: 23
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 63592
Country/Territory United States
Received
2021-01-29 21:50
Peer-Review Started
2021-01-29 21:56
To Make the First Decision
Return for Revision
2021-04-06 05:39
Revised
2021-04-13 22:14
Second Decision
2021-05-10 09:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-05-10 09:49
Articles in Press
2021-05-10 09:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-06-03 00:36
Publish the Manuscript Online
2021-06-07 11:17
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Harold W Davis, Ahmet Kaynak, Subrahmanya D Vallabhapurapu and Xiaoyang Qi
Funding Agency and Grant Number
Funding Agency Grant Number
Pancreatic Cancer Action Network Translational Research Grant 20-65-QIXI
Give Hope Foundation, National Institutes of Health R01CA158372
Give Hope Foundation, National Institutes of Health R21NS095047
CCTST Pilot Collaborative Studies, Bearcats Against Cancer, and Hematology-Oncology Programmatic Support from University of Cincinnati College of Medicine
Corresponding Author Xiaoyang Qi, PhD, Professor, Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Brain Tumor Center at UC Neuroscience Institute, 3512 Eden Avenue, Cincinnati, OH 45267, United States. xiaoyang.qi@uc.edu
Key Words Pancreatic cancer; Saposin C; Dioleoylphosphatidylserine; Phosphatidylserine-targeted therapy; Chemotherapy; Radiation
Core Tip This review presents the mechanisms and efficacy of saposin C-dioleoylphosphatidylserine (SapC-DOPS), a novel phosphatidylserine (PS) biomarker-targeted nanodrug, alone and in combination with other treatment modalities for the treatment of pancreatic ductal adenocarcinoma (PDAC) tumors. Our results indicate that SapC-DOPS preferentially targets cells with high surface PS which are primarily in the G2/M phase of the cell cycle. Other treatment modalities such as Gemcitabine, Abraxane and radiation target G1 phase cells that have low surface PS. Combination of SapC-DOPS and Gemcitabine/Abraxane or radiation significantly inhibits tumor growth of orthotopic PDAC tumors in vivo and increases survival compared to individual treatments.
Publish Date 2021-06-07 11:17
Citation Davis HW, Kaynak A, Vallabhapurapu SD, Qi X. Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer. World J Gastrointest Oncol 2021; 13(6): 550-559
URL https://www.wjgnet.com/1948-5204/full/v13/i6/550.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i6.550
Full Article (PDF) WJGO-13-550.pdf
Full Article (Word) WJGO-13-550.docx
Manuscript File 63592_Auto_Edited-ZMG.docx
Answering Reviewers 63592-Answering reviewers.pdf
Audio Core Tip 63592-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 63592-Conflict-of-interest statement.pdf
Copyright License Agreement 63592-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 63592-Grant application form(s).pdf
Peer-review Report 63592-Peer-review(s).pdf
Scientific Misconduct Check 63592-Bing-Yan JP-1.jpg
Scientific Misconduct Check 63592-Scientific misconduct check.pdf
Scientific Editor Work List 63592-Scientific editor work list.pdf