Publication Name	World Journal of Diabetes
Manuscript ID	63835
Country	Mexico

Received	2021-02-03 15:27
Peer-Review Started	2021-02-03 15:44
To Make the First Decision
Return for Revision	2021-03-01 00:52
Revised	2021-04-16 18:48
Second Decision	2021-06-16 13:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-16 13:54
Articles in Press	2021-06-16 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-27 14:27
Publish the Manuscript Online	2021-07-12 05:45

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Immunometabolic bases of type 2 diabetes in the severity of COVID-19
Manuscript Source	Invited Manuscript
All Author List	Rebeca Viurcos-Sanabria and Galileo Escobedo
Funding Agency and Grant Number	Funding Agency Grant Number Fondo Sectorial de Investigación para la Educación-CONACYT-México CB-2016-01-286209 Fondo Sectorial de Investigación y Desarrollo en Salud y Seguridad Social SS/IMSS/ISSSTE/CONACYT-México SALUD-2017-02-290345
Corresponding Author	Galileo Escobedo, PhD, Full Professor, Laboratorio de Proteómica, Dirección de Investigación, Hospital General de Mexico “Dr. Eduardo Liceaga”, Dr. Balmis 148, Mexico City 06720, Mexico. gescobedog@msn.com
Key Words	COVID-19; SARS-CoV-2; Type 2 Diabetes; Inflammation; Hyperglycemia; Prothrombotic state
Core Tip	Type 2 diabetes (T2D) acts in synergy with severe acute respiratory syndrome coronavirus-2 infection to increase the progression, severity, and mortality of coronavirus disease 2019 (COVID-19). Thus, the immunometabolic bases of the main etiological factors of T2D that contribute to the severity of COVID-19 should be studied. Here, we discuss the molecular mechanisms by which immune cells, hyperglycemia, hyperinsulinemia, loss of pancreatic β-cell mass, insulin resistance, advanced glycation end products, endothelial dysfunction, and prothrombotic state contribute to the severity of COVID-19. The syndemic between COVID-19 and T2D has challenged our ability to identify patients with high mortality risk based on scientific evidence.
Publish Date	2021-07-12 05:45
Citation	Viurcos-Sanabria R, Escobedo G. Immunometabolic bases of type 2 diabetes in the severity of COVID-19. World J Diabetes 2021; 12(7): 1026-1041
URL	https://www.wjgnet.com/1948-9358/full/v12/i7/1026.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i7.1026

Full Article (PDF)	WJD-12-1026.pdf
Full Article (Word)	WJD-12-1026.docx
Manuscript File	63835_Auto_Edited-ZMG.docx
Answering Reviewers	63835-Answering reviewers.pdf
Audio Core Tip	63835-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63835-Conflict-of-interest statement.pdf
Copyright License Agreement	63835-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63835-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	63835-Language certificate.pdf
Peer-review Report	63835-Peer-review(s).pdf
Scientific Misconduct Check	63835-Scientific misconduct check.pdf
Scientific Editor Work List	63835-Scientific editor work list.pdf