Publication Name	World Journal of Critical Care Medicine
Manuscript ID	63892
Country	United States

Received	2021-02-05 01:18
Peer-Review Started	2021-02-05 01:21
To Make the First Decision
Return for Revision	2021-03-17 03:36
Revised	2021-03-21 05:55
Second Decision	2021-06-15 12:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-15 13:19
Articles in Press	2021-06-15 13:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-21 02:56
Publish the Manuscript Online	2021-07-06 23:59

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Systematic Reviews
Article Title	SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Santosh Shenoy
Funding Agency and Grant Number
Corresponding Author	Santosh Shenoy, MD, Professor, Department of General and Colorectal Surgery, KCVA and University of Missouri at Kansas City, 4801 E Linwood Blvd., Missouri, MO 64128, United States. shenoy2009@hotmail.com
Key Words	COVID-19; SARS-CoV-2; Viral load; Severe sepsis; Dynamics; Mortality
Core Tip	High viral load in Coronavirus-2 infections is an independent predictor of disease severity, mortality and prognosis. However there is a wide heterogeneity in fluid samples at different phases of the disease and data should be interpreted with caution. In aggregate, observations support the hypothesis of checking and reporting viral load by quantitative real time reverse transcriptase polymerase chain reaction, instead of binary assessment of a test being positive or negative. Longitudinal analysis with viral loads should be conducted for interpretation of outcome data. This may be the guiding principle for therapy and infection control policies for future pandemics.
Publish Date	2021-07-06 23:59
Citation	Shenoy S. SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review. World J Crit Care Med 2021; 10(4): 132-150
URL	https://www.wjgnet.com/2220-3141/full/v10/i4/132.htm
DOI	https://dx.doi.org/ 10.5492/wjccm.v10.i4.132

Full Article (PDF)	WJCCM-10-132.pdf
Full Article (Word)	WJCCM-10-132.docx
PRISMA 2009 Checklist	63892-PRISMA-2009-Checklist-revision.pdf
Manuscript File	63892_Auto_Edited-ZMG.docx
Answering Reviewers	63892-Answering reviewers.pdf
Audio Core Tip	63892-Audio core tip.m4a
Biostatistics Review Certificate	63892-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	63892-Conflict-of-interest statement.pdf
Copyright License Agreement	63892-Copyright license agreement.pdf
Peer-review Report	63892-Peer-review(s).pdf
Scientific Misconduct Check	63892-Bing Liu M-1.png
Scientific Misconduct Check	63892-Bing Liu M-2.png
Scientific Misconduct Check	63892-Scientific misconduct check.pdf
Scientific Editor Work List	63892-Scientific editor work list.pdf