Publication Name	World Journal of Clinical Oncology
Manuscript ID	64445
Country	Argentina

Received	2021-02-17 19:41
Peer-Review Started	2021-02-17 19:45
To Make the First Decision
Return for Revision	2021-03-17 02:48
Revised	2021-03-26 18:47
Second Decision	2021-06-02 11:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-02 13:06
Articles in Press	2021-06-02 13:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-17 03:25
Publish the Manuscript Online	2021-06-21 06:41

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Breast cancer: Muscarinic receptors as new targets for tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Alejandro Español, Agustina Salem, Yamila Sanchez and Maria Elena Sales
Funding Agency and Grant Number	Funding Agency Grant Number National Agency for Scientific and Technological Promotion (ANPCyT) 2015-2396
Corresponding Author	Alejandro Español, PhD, Research Scientist, Laboratory of Immunopharmacology and Tumor Biology, CEFYBO CONICET University of Buenos Aires, Paraguay 2155 piso 16 Sector izq, Buenos Aires C1121ABG, Argentina. aespan_1999@yahoo.com
Key Words	Muscarinic receptors; Drug therapy; Breast cancer; Drug combination; Metronomic therapy; Drug resistance
Core Tip	Muscarinic acetylcholine receptors should be considered as new targets in breast cancer therapy since they are expressed in breast tumor tissue but not in normal tissue. The addition of muscarinic agonists at low concentrations combined with traditional chemotherapeutic drugs presents promising results. The administration of these combinations in a metronomic schedule is effective to kill tumor cells, reduce tumor invasion and neoangiogenesis. Promising results have also been reported regarding the expression of drug extrusion pumps and the decrease of the cancer stem cell fraction, which would be useful to reduce resistance to traditional chemotherapy and the relapse of breast cancer.
Publish Date	2021-06-21 06:41
Citation	Español A, Salem A, Sanchez Y, Sales ME. Breast cancer: Muscarinic receptors as new targets for tumor therapy. World J Clin Oncol 2021; 12(6): 404-428
URL	https://www.wjgnet.com/2218-4333/full/v12/i6/404.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i6.404

Full Article (PDF)	WJCO-12-404.pdf
Full Article (Word)	WJCO-12-404.docx
Manuscript File	64445_Auto_Edited-ZMG.docx
Answering Reviewers	64445-Answering reviewers.pdf
Audio Core Tip	64445-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	64445-Conflict-of-interest statement.pdf
Copyright License Agreement	64445-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64445-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	64445-Language certificate.pdf
Peer-review Report	64445-Peer-review(s).pdf
Scientific Misconduct Check	64445-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64445-Scientific misconduct check.pdf
Scientific Editor Work List	64445-Scientific editor work list.pdf
CrossCheck Report	64445-CrossCheck report.pdf