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8/10/2021 7:12:32 AM | Browse: 413 | Download: 990
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Received |
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2021-02-20 19:20 |
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Peer-Review Started |
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2021-02-20 19:24 |
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To Make the First Decision |
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Return for Revision |
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2021-05-01 17:38 |
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Revised |
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2021-05-22 19:32 |
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Second Decision |
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2021-07-26 03:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-27 07:52 |
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Articles in Press |
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2021-07-27 07:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-08-09 02:23 |
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Publish the Manuscript Online |
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2021-08-10 06:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Assessing disease activity using the pediatric Crohn’s disease activity index: Can we use subjective or objective parameters alone?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Amy Grant, Trudy Lerer, Anne M Griffiths, JS Hyams and Anthony Otley |
| Funding Agency and Grant Number |
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| Corresponding Author |
Anthony Otley, FRCPC, MD, Doctor, Doctor, Professor, Division of Pediatrics, Dalhousie University, 5850/5980 University Avenue Halifax, Halifax B3H4C3, NS, Canada. arotley@dal.ca |
| Key Words |
Crohn’s disease; Pediatric Crohn’s disease activity index; Patient reported outcome measurement; Disease activity; Clinical trials; Pediatric |
| Core Tip |
The pediatric Crohn’s disease activity index (PCDAI) is commonly used to assess disease activity in clinical trials. The PCDAI is a multi-item index incorporating subjective (e.g., patient well-being) and objective (e.g., laboratory tests) items. In response to a call from the Food and Drug Administration our team reexamined functioning of this index. Although subjective items on the PCDAI changed the most over time, the full PCDAI or a smaller composite of items that includes both subjective and objective components better classifies disease activity. Use of subjective or objective items on their own may result in misclassification of disease state. |
| Publish Date |
2021-08-10 06:48 |
| Citation |
Grant A, Lerer T, Griffiths AM, Hyams J, Otley A. Assessing disease activity using the pediatric Crohn’s disease activity index: Can we use subjective or objective parameters alone? World J Gastroenterol 2021; 27(30): 5100-5111 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i30/5100.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i30.5100 |
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