Publication Name	World Journal of Gastroenterology
Manuscript ID	64598
Country	Japan

Received	2021-02-27 02:07
Peer-Review Started	2021-02-27 02:12
To Make the First Decision
Return for Revision	2021-03-28 00:04
Revised	2021-04-10 22:37
Second Decision	2021-09-02 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-02 07:31
Articles in Press	2021-09-02 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-06 03:07
Typeset the Manuscript	2022-03-30 08:01
Publish the Manuscript Online	2022-04-06 08:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Basic Study
Article Title	Syngeneic implantation of mouse hepatic progenitor cell-derived three-dimensional liver tissue with dense collagen fibrils
Manuscript Source	Invited Manuscript
All Author List	Miho Tamai, Eijiro Adachi, Masaya Kawase and Yoh-ichi Tagawa
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aid for Scientific Research (A) 25242040 Grants-in-Aid for Challenging Exploratory Research 20K21520 Grants-in-Aid for Early Career Scientists from the Japan Society for the Promotion of Science (JSPS) 19K20655 Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) 231190003 Japan Agency for Medical Research and Development (AMED) 20fk0310102 Building of Consortia for the Development of Human Resources in Science and Technology, Ministry of Education, Culture, Sports, Science and Technology, Japan
Corresponding Author	Yoh-ichi Tagawa, DSc, Associate Professor, School of Life Science and Technology, Tokyo Institute of Technology, 4259 B51, Nagatsuta-cho, Midori-ku, Yokohama-shi 226-8501, Japan. ytagawa@bio.titech.ac.jp
Key Words	Liver; Three-dimensional tissue culture; Hepatic progenitor cells; Angiogenesis; Biomimetic extracellular matrix
Core Tip	Liver transplantation is a therapeutic procedure used to recover liver function in patients with irreversible liver failure; however, presently there is a shortage of transplant organs available. Hepatic stem and progenitor cells are expected to allow regenerative medicine to produce a cell source as an alternative to whole organs. The portal branch-ligated, hepatic lobe-derived hepatic progenitor cells multiplied in a bioreactor chamber to form liver organoid tissues comparable to liver lobules. These organoid tissues were implanted into syngeneic mice. This portal branch-ligated-derived hepatic progenitor cell line has the potential to proliferate, mature, and form implantable hepatic tissue.
Publish Date	2022-04-06 08:50
Citation	Tamai M, Adachi E, Kawase M, Tagawa YI. Syngeneic implantation of mouse hepatic progenitor cell-derived three-dimensional liver tissue with dense collagen fibrils. World J Gastroenterol 2022; 28(14): 1444-1454
URL	https://www.wjgnet.com/1007-9327/full/v28/i14/1444.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i14.1444

Full Article (PDF)	WJG-28-1444.pdf
Full Article (Word)	WJG-28-1444.docx
Manuscript File	64598_Auto_Edited-Webster J.docx
Answering Reviewers	64598-Answering reviewers.pdf
Audio Core Tip	64598-Audio core tip.mp3
Biostatistics Review Certificate	64598-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	64598-Conflict-of-interest statement.pdf
Copyright License Agreement	64598-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64598-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	64598-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	64598-Language certificate.pdf
Supplementary Material	64598-Supplementary material.pdf
Peer-review Report	64598-Peer-review(s).pdf
Scientific Misconduct Check	64598-Scientific misconduct check.pdf
Scientific Editor Work List	64598-Scientific editor work list.pdf