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6/7/2021 12:50:08 PM | Browse: 25 | Download: 13
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 64660
Country/Territory United States
Received
2021-02-21 20:53
Peer-Review Started
2021-02-21 20:56
To Make the First Decision
Return for Revision
2021-04-19 17:29
Revised
2021-05-02 16:34
Second Decision
2021-05-14 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-05-15 05:06
Articles in Press
2021-05-15 05:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-05-28 12:00
Publish the Manuscript Online
2021-06-07 11:17
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer
Manuscript Source Invited Manuscript
All Author List Manasa Suresh and Stephan Menne
Funding Agency and Grant Number
Corresponding Author Stephan Menne, PhD, Associate Professor, Department of Microbiology & Immunology, Georgetown University Medical Center, 3rd Floor, Medical-Dental Building, 3900 Reservoir Road, Washington, DC 20057, United States. stephan.menne@georgetown.edu
Key Words Woodchuck; Hepatitis B virus; Chronic infection; Liver disease; Hepatocellular carcinoma; Cancer treatment
Core Tip Hepatitis B virus-induced liver tumors are hard to treat with currently available interventions and the prognosis of hepatocellular carcinoma (HCC) in patients remains still poor. Immunocompetent woodchucks are a useful animal model for human HCC, because multiple tumors at different stages develop spontaneously and secondary to viral infection. This similarity to human hepatocarcinogenesis and the animal’s vascular architecture allowing catheterization with human-sized products have increased the preclinical use of this model to improve existing imaging (ultrasound, magnetic resonance imaging, and positron-emission tomography) and ablation techniques (embolization and radiotherapy) and to evaluate interventions (chemo, gene, and immune therapy) intended to treat human HCC.
Publish Date 2021-06-07 11:17
Citation Suresh M, Menne S. Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer. World J Gastrointest Oncol 2021; 13(6): 509-535
URL https://www.wjgnet.com/1948-5204/full/v13/i6/509.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i6.509
Full Article (PDF) WJGO-13-509.pdf
Full Article (Word) WJGO-13-509.docx
Manuscript File 64660_Auto_Edited.docx
Answering Reviewers 64660-Answering reviewers.pdf
Audio Core Tip 64660-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 64660-Conflict-of-interest statement.pdf
Copyright License Agreement 64660-Copyright license agreement.pdf
Peer-review Report 64660-Peer-review(s).pdf
Scientific Misconduct Check 64660-Bing-Wang JL-1.jpg
Scientific Misconduct Check 64660-CrossCheck.png
Scientific Misconduct Check 64660-Scientific misconduct check.pdf
Scientific Editor Work List 64660-Scientific editor work list.pdf