Publication Name	World Journal of Stem Cells
Manuscript ID	64663
Country	United States

Received	2021-02-21 22:04
Peer-Review Started	2021-02-21 22:08
To Make the First Decision
Return for Revision	2021-04-20 02:30
Revised	2021-05-03 13:58
Second Decision	2021-06-22 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-22 10:02
Articles in Press	2021-06-22 10:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-21 13:52
Publish the Manuscript Online	2021-07-23 13:30

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Review
Article Title	Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair
Manuscript Source	Invited Manuscript
All Author List	Bruno C Menarim, James N MacLeod and Linda A Dahlgren
Funding Agency and Grant Number
Corresponding Author	Bruno C Menarim, DVM, MSc, PhD, Senior Postdoctoral Fellow, Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, Food and Environment, University of Kentucky, 1400 Nicholasville , Lexington, KY 40546, United States. bruno.menarim@uky.edu
Key Words	Osteoarthritis; Arthropathy; Synovitis; Hematopoietic progenitor; Homeostasis; Cell therapy
Core Tip	Synovial macrophages are essential for joint integrity. Following injury, macrophages incite inflammation recruiting more macrophages from the bone marrow to counteract damage and promote tissue repair. Synovial macrophages are further essential to resolve inflammation recovering joint homeostasis. However, sustained damage frequently overwhelms pro-resolving functions of synovial macrophages, leading to chronic inflammation and degeneration. This review summarizes the dual role of macrophages in the maintenance of joint homeostasis and the emergent therapeutic use of macrophage progenitors isolated from the bone marrow to promote endogenous resolution of joint inflammation and recovery of homeostasis, while preserving physiological mechanisms negatively affected by anti-inflammatories.
Publish Date	2021-07-23 13:30
Citation	Menarim BC, MacLeod JN, Dahlgren LA. Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair. World J Stem Cells 2021; 13(7): 825-840
URL	https://www.wjgnet.com/1948-0210/full/v13/i7/825.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i7.825

Full Article (PDF)	WJSC-13-825.pdf
Full Article (Word)	WJSC-13-825.docx
Manuscript File	64663_Auto_Edited-JPY.docx
Answering Reviewers	64663-Answering reviewers.pdf
Audio Core Tip	64663-Audio core tip.wav
Conflict-of-Interest Disclosure Form	64663-Conflict-of-interest statement.pdf
Copyright License Agreement	64663-Copyright license agreement.pdf
Supplementary Material	64663-Copyright permission (Figures 2 and 3).pdf
Peer-review Report	64663-Peer-review(s).pdf
Scientific Misconduct Check	64663-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64663-Bing-Liu M-2.png
Scientific Misconduct Check	64663-Scientific misconduct check.pdf
Scientific Editor Work List	64663-Scientific editor work list.pdf