| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
CircRNA_0084927 promoted colorectal cancer progression by regulating the miRNA-20b-3p/glutathione S-transferase mu 5 axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng Liu, Xiao-Li Xiao, Yu-Jing Liu, Ruo-Hui Xu, Wen-Jun Zhou, Han-Chen Xu, Ai-Guang Zhao, Yang-Xian Xu, Yan-Qi Dang and Guang Ji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81804018 |
| National Natural Science Foundation of China (General Program) |
81874206 |
| Key project of the Shanghai 3-Year Plan |
ZY[2018-2020]CCCX-2002-01 |
|
| Corresponding Author |
Guang Ji, MD, Chairman, Professor, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com |
| Key Words |
Colorectal cancer; CircRNA_0084927; MiRNA-20b-3p; Glutathione S-transferase mu 5; Migration; Invasion |
| Core Tip |
The five-year survival rate of patients with early-stage colorectal cancer (CRC) could reach 90%, but the five-year survival rate of patients with advanced-stage CRC was very low. Recent studies have shown that circular RNAs play important roles in regulating the migration and invasion of CRC. To elucidate the role of circRNA_0084927 (circ_0084927), the study was performed. The expression of circ_0084927 was significantly increased in CRC tissues and cells, and was markedly increased in advanced-stage CRC compared with early-stage CRC. Knockdown of circ_0084927 inhibited the migration and invasion of HCT116 cells. Moreover, circ_0084927 potentially regulates CRC migration and invasion via the miRNA-20b-3p/glutathione S-transferase mu 5 pathway. |
| Publish Date |
2021-09-23 07:48 |
| Citation |
Liu F, Xiao XL, Liu YJ, Xu RH, Zhou WJ, Xu HC, Zhao AG, Xu YX, Dang YQ, Ji G. CircRNA_0084927 promoted colorectal cancer progression by regulating the miRNA-20b-3p/glutathione S-transferase mu 5 axis. World J Gastroenterol 2021; 27(36): 6064-6078 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i36/6064.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i36.6064 |
