Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	65406
Country	Türkiye

Received	2021-03-06 06:06
Peer-Review Started	2021-03-06 06:10
To Make the First Decision
Return for Revision	2021-04-19 03:08
Revised	2021-04-20 08:39
Second Decision	2021-05-25 14:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-25 15:22
Articles in Press	2021-05-25 15:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-15 06:41
Typeset the Manuscript	2021-07-08 11:33
Publish the Manuscript Online	2021-07-10 10:08

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Systems-level biomarkers identification and drug repositioning in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Hande Beklen, Esra Yildirim, Medi Kori, Beste Turanli and Kazim Yalcin Arga
Funding Agency and Grant Number	Funding Agency Grant Number TUBITAK (Hande Beklen and Kazim Yalcin Arga) 119S174 Marmara University Research Fund (BAPKO) FEN-C-YLP-120619-0199
Corresponding Author	Kazim Yalcin Arga, PhD, Professor, Department of Bioengineering, Marmara University, Goztepe, Istanbul 34722, Türkiye. kazim.arga@marmara.edu.tr
Key Words	Colorectal cancer; Colon cancer; Systems biology; Biomarker; Drug repositioning; Omics
Core Tip	Colorectal cancer (CRC) is the most commonly diagnosed cancer in women and men worldwide. Due to the lack of clinical symptoms, it is difficult for CRC patients to diagnose it in the early stages. There is an urgent need for alternative, inexpensive and easy-to-measure methods for screening and therapy. Systems biology and drug repositioning (DR) approaches are being used to discover biomarkers and novel targets as well as, existing drugs with different indications to develop new therapeutics and treatment strategies. Our goal was to provide an overview of systems-level biomarkers and insights into DR strategies for the treatment of CRC.
Publish Date	2021-07-10 10:08
Citation	Beklen H, Yildirim E, Kori M, Turanli B, Arga KY. Systems-level biomarkers identification and drug repositioning in colorectal cancer. World J Gastrointest Oncol 2021; 13(7): 638-661
URL	https://www.wjgnet.com/1948-5204/full/v13/i7/638.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i7.638

Full Article (PDF)	WJGO-13-638.pdf
Full Article (Word)	WJGO-13-638.docx
Manuscript File	65406_Auto_Edited-ZMG-Webster J-Clear.docx
Answering Reviewers	65406-Answering reviewers.pdf
Audio Core Tip	65406-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65406-Conflict-of-interest statement.pdf
Copyright License Agreement	65406-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65406-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	65406-Language certificate.pdf
Peer-review Report	65406-Peer-review(s).pdf
Scientific Misconduct Check	65406-Bing-Wang JL-1.jpg
Scientific Misconduct Check	65406-Bing-Fan JR-2.png
Scientific Misconduct Check	65406-Scientific misconduct check.pdf
Scientific Editor Work List	65406-Scientific editor work list.pdf