Publication Name	World Journal of Stem Cells
Manuscript ID	65667
Country	Spain

Received	2021-03-12 14:02
Peer-Review Started	2021-03-12 14:09
To Make the First Decision
Return for Revision	2021-05-05 14:39
Revised	2021-05-13 06:34
Second Decision	2021-08-18 03:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-18 08:09
Articles in Press	2021-08-18 08:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-17 02:54
Publish the Manuscript Online	2021-09-18 09:35

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer
Manuscript Source	Invited Manuscript
All Author List	Alba Royo-Garcia, Sarah Courtois, Beatriz Parejo-Alonso, Pilar Espiau-Romera and Patricia Sancho
Funding Agency and Grant Number	Funding Agency Grant Number Miguel Servet Fellowship CP16/00121 FIS (Fondo Investigaciones Sanitarias) grants PI17/00082 FIS (Fondo Investigaciones Sanitarias) grants PI20/00942 the Worldwide Cancer Research Charity together with Fundación Científica Asociación Española contra el Cáncer (FCAECC) 19-0250
Corresponding Author	Patricia Sancho, PhD, Senior Researcher, Hospital Universitario Miguel Servet, IIS Aragon, Isabel la Catolica 1-3, Zaragoza 50009, Spain. psancho@iisaragon.es
Key Words	Lipids; Lipid droplets; Lipid metabolism; Stemness; Cancer stem cells; Chemoresistance
Core Tip	Increasing evidence suggests that lipid droplets (LDs) support cancer stem cells (CSCs) functionality at different levels. Indeed, an increased LD content has been linked to tumorigenicity, metastatic spread and chemoresistance in different cancer types, highlighting their value as prognostic and treatment response predictive biomarker. A deeper understanding of the molecular mechanisms by which LDs control these processes would expedite the discovery of novel potentially druggable targets and the design of more efficient therapeutic strategies aimed at eliminating highly tumorigenic CSCs.
Publish Date	2021-09-18 09:35
Citation	Royo-García A, Courtois S, Parejo-Alonso B, Espiau-Romera P, Sancho P. Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer. World J Stem Cells 2021; 13(9): 1307-1317
URL	https://www.wjgnet.com/1948-0210/full/v13/i9/1307.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i9.1307

Full Article (PDF)	WJSC-13-1307.pdf
Full Article (Word)	WJSC-13-1307.docx
Manuscript File	65667_Auto_Edited-JLW.docx
Answering Reviewers	65667-Answering reviewers.pdf
Audio Core Tip	65667-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65667-Conflict-of-interest statement.pdf
Copyright License Agreement	65667-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65667-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	65667-Language certificate.pdf
Peer-review Report	65667-Peer-review(s).pdf
Scientific Misconduct Check	65667-Scientific misconduct check.pdf
Scientific Editor Work List	65667-Scientific editor work list.pdf