Publication Name	World Journal of Gastroenterology
Manuscript ID	65779
Country	Türkiye

Received	2021-03-15 18:57
Peer-Review Started	2021-03-15 19:20
To Make the First Decision
Return for Revision	2021-06-03 22:53
Revised	2021-06-14 14:18
Second Decision	2021-11-24 03:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-25 01:28
Articles in Press	2021-11-25 01:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-30 23:50
Publish the Manuscript Online	2021-12-03 07:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Orosomucoid in liver diseases
Manuscript Source	Invited Manuscript
All Author List	Gulsum Ozlem Elpek
Funding Agency and Grant Number
Corresponding Author	Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Orosomucoid; Alpha-1-acid glycoprotein; Viral hepatitis; cirrhosis; Hepatocellular carcinoma; Downregulation
Core Tip	Orosomucoid (ORM) has been suggested as a noninvasive marker in the diagnosis and follow-up of liver diseases. Currently, the results support the hypothesis that ORM can be used together with other markers to diagnose acute liver failure, monitor the development of cirrhosis, and detect early hepatocellular carcinoma (HCC). Although its role in carcinogenesis has not been entirely determined, the fact that decreased ORM2 expression is associated with carcinogenesis and poor prognosis warrants further study with the aim of better understanding the role of ORM in tumor behavior. The use of ORM expression to distinguish HCC from other neoplastic lesions and its role in differential diagnosis await investigation.
Publish Date	2021-12-03 07:34
Citation	Elpek GO. Orosomucoid in liver diseases. World J Gastroenterol 2021; 27(45): 7739-7747
URL	https://www.wjgnet.com/1007-9327/full/v27/i45/7739.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i45.7739

Full Article (PDF)	WJG-27-7739.pdf
Full Article (Word)	WJG-27-7739.docx
Manuscript File	65779_Auto_Edited.docx
Answering Reviewers	65779-Answering reviewers.pdf
Audio Core Tip	65779-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65779-Conflict-of-interest statement.pdf
Copyright License Agreement	65779-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65779-Language certificate.pdf
Peer-review Report	65779-Peer-review(s).pdf
Scientific Misconduct Check	65779-Bing-Liu M-1.png
Scientific Misconduct Check	65779-Bing-Gao CC-2.png
Scientific Editor Work List	65779-Scientific editor work list.pdf
CrossCheck Report	65779-CrossCheck report.pdf