BPG is committed to discovery and dissemination of knowledge
Featured Articles
7/26/2021 12:19:47 PM | Browse: 428 | Download: 715
Publication Name World Journal of Gastroenterology
Manuscript ID 65980
Country/Territory China
Received
2021-03-19 03:36
Peer-Review Started
2021-03-19 03:39
To Make the First Decision
Return for Revision
2021-06-03 22:43
Revised
2021-06-04 14:43
Second Decision
2021-06-22 14:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-06-22 14:34
Articles in Press
2021-06-22 14:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-07-01 04:59
Typeset the Manuscript
2021-07-21 12:43
Publish the Manuscript Online
2021-07-26 11:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Ting Liu, Xiao-Li Xie, Xue Zhou, Sheng-Xiong Chen, Yi-Jun Wang, Lin-Ping Shi, Shu-Jia Chen, Yong-Juan Wang, Shu-Ling Wang, Jiu-Na Zhang, Shi-Ying Dou, Xiao-Yu Jiang, Ruo-Lin Cui and Hui-Qing Jiang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81770601
National Natural Science Foundation of China 81702324
National Natural Science Foundation of China 81602529
Natural Science Foundation of Hebei Province H2018206176
Natural Science Foundation of Hebei Province H2017206141
Post-graduate’s Innovation Fund Project of Hebei Province CXZZBS2019121
Corresponding Author Hui-Qing Jiang, MD, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. jianghq@aliyun.com
Key Words Y-box binding protein 1; Hepatocellular carcinoma; Sorafenib; Drug resistance; Phosphoinositide-3-kinase/protein kinase B
Core Tip Y-box binding protein 1 (YB-1) was significantly increased in hepatocellular carcinoma (HCC), and it could increase the IC50 values of sorafenib in HCC cell lines. Meanwhile, YB-1 suppressed apoptosis and cell proliferation inhibition induced by sorafenib. Furthermore, we screened the phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway to explore the molecular mechanism of sorafenib resistance by the KEGG pathway enrichment analysis of the digital gene expression profiling-seq. And the blockade of PI3K/Akt signaling pathway by LY294002 mitigated YB-1-induced sorafenib resistance. Given that sorafenib is the first-line treatment for patients with advanced HCC, we proposed that the down-regulation of YB-1 is of great significance for the application of sorafenib in advanced HCC.
Publish Date 2021-07-26 11:20
Citation Liu T, Xie XL, Zhou X, Chen SX, Wang YJ, Shi LP, Chen SJ, Wang YJ, Wang SL, Zhang JN, Dou SY, Jiang XY, Cui RL, Jiang HQ. Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma. World J Gastroenterol 2021; 27(28): 4667-4686
URL https://www.wjgnet.com/1007-9327/full/v27/i28/4667.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i28.4667
Full Article (PDF) WJG-27-4667.pdf
Full Article (Word) WJG-27-4667.docx
The ARRIVE Guidelines 65980-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 65980_Review-FilipodiaCL.docx
Answering Reviewers 65980-Answering reviewers.pdf
Audio Core Tip 65980-Audio core tip.m4a
Biostatistics Review Certificate 65980-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 65980-Conflict-of-interest statement.pdf
Copyright License Agreement 65980-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 65980-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 65980-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 65980-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 65980-Language certificate.pdf
Supplementary Material 65980-Supplementary material.pdf
Peer-review Report 65980-Peer-review(s).pdf
Scientific Misconduct Check 65980-Scientific misconduct check.pdf
Scientific Editor Work List 65980-Scientific editor work list.pdf