Publication Name	World Journal of Nephrology
Manuscript ID	66270
Country	Egypt

Received	2021-04-25 08:55
Peer-Review Started	2021-04-25 08:57
To Make the First Decision
Return for Revision	2021-06-06 03:32
Revised	2021-06-16 23:41
Second Decision	2021-07-22 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-22 09:12
Articles in Press	2021-07-22 09:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-04 01:55
Typeset the Manuscript	2021-08-06 02:56
Publish the Manuscript Online	2021-08-06 07:03

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Lower urinary tract dysfunction in pediatrics progress to kidney disease in adolescents: Toward precision medicine in treatment
Manuscript Source	Invited Manuscript
All Author List	Mohamed Wishahi
Funding Agency and Grant Number
Corresponding Author	Mohamed Wishahi, MD, PhD, Professor, Department of Urology, Theodor Bilharz Research Institute, Embaba-Giza, Cairo 12411, Egypt. moh.weshahy@gmail.com
Key Words	Neurogenic bladder dysfunction; Antimuscarinics; OnabotulinumtoxinA; Neural stimulations; Renal transplantations
Core Tip	Neurogenic bladder dysfunction (NBD) in children would end with deleterious effect on the upper tract that end with renal dysfunction and chronic kidney failure. There are several reviews in the literature contributed to the therapeutic options of NBD in children. However, this review report treatment options including the latest modalities. The new anti-muscarinic drugs have minimal adverse effect, high tolerability, availability of solution form, and dose adjustment. Children who develop adverse events from antimuscarinics, or non-compliant to clean intermittent catheterization, would be candidate for detrusor muscle injection with onabotulinumtoxinA which proved to be safe with no adverse effects. Kidney transplantation would be the last resort for treatment of child when who have progressive deterioration of kidney function.
Publish Date	2021-08-06 07:03
Citation	Wishahi M. Lower urinary tract dysfunction in pediatrics progress to kidney disease in adolescents: Toward precision medicine in treatment. World J Nephrol 2021; 10(4): 37-46
URL	https://www.wjgnet.com/2220-6124/full/v10/i4/37.htm
DOI	https://dx.doi.org/10.5527/wjn.v10.i4.37

Full Article (PDF)	WJN-10-37.pdf
Full Article (Word)	WJN-10-37.docx
Manuscript File	66270-Review-FilipodiaCL.docx
Answering Reviewers	66270-Answering reviewers.pdf
Audio Core Tip	66270-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66270-Conflict-of-interest statement.pdf
Copyright License Agreement	66270-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	66270-Language certificate.pdf
Peer-review Report	66270-Peer-review(s).pdf
Scientific Misconduct Check	66270-Bing-Fan JR-2.png
Scientific Misconduct Check	66270-Scientific misconduct check.pdf
Scientific Editor Work List	66270-Scientific editor work list.pdf