Publication Name	World Journal of Biological Chemistry
Manuscript ID	66402
Country	Japan

Received	2021-03-27 01:05
Peer-Review Started	2021-03-27 01:09
To Make the First Decision
Return for Revision	2021-07-27 06:23
Revised	2021-08-06 08:41
Second Decision	2021-12-16 03:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-23 06:24
Articles in Press	2021-12-23 06:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-19 17:20
Publish the Manuscript Online	2022-01-22 06:08

ISSN	1949-8454 (online)
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Category	Immunology
Manuscript Type	Minireviews
Article Title	Current understanding of the role of tyrosine kinase 2 signaling in immune responses
Manuscript Source	Invited Manuscript
All Author List	Ryuta Muromoto, Kenji Oritani and Tadashi Matsuda
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology of Japan 19H03364 Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology of Japan 20K07010
Corresponding Author	Tadashi Matsuda, PhD, Professor, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita12 Nishi 6, Sapporo 0600812, Japan. tmatsuda@pharm.hokudai.ac.jp
Key Words	Tyrosine kinase 2; Cytokines; Signal transduction; Immune system; Inflammation
Core Tip	Studies on murine tyrosine kinase 2 (Tyk2)-deficient models were reviewed to examine the role of Tyk2 dysregulation in human diseases. Tyk2-deficient mice exhibit reduced responses in several interleukin-12 (IL-12)/Th1- and IL-23/Th17-mediated models of diseases, including rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, psoriasis, sarcoidosis, and delayed-type hypersensitivity. These findings demonstrate a broad contribution of Tyk2 to immune responses. Tyk2 represents a candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes.
Publish Date	2022-01-22 06:08
Citation	Muromoto R, Oritani K, Matsuda T. Current understanding of the role of tyrosine kinase 2 signaling in immune responses. World J Biol Chem 2022; 13(1): 1-14
URL	https://www.wjgnet.com/1949-8454/full/v13/i1/1.htm
DOI	https://dx.doi.org/10.4331/wjbc.v13.i1.1

Full Article (PDF)	WJBC-13-1.pdf
Full Article (Word)	WJBC-13-1.docx
Manuscript File	66402_Auto_Edited-A.docx
Answering Reviewers	66402-Answering reviewers.pdf
Audio Core Tip	66402-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	66402-Conflict-of-interest statement.pdf
Copyright License Agreement	66402-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	66402-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	66402-Language certificate.pdf
Peer-review Report	66402-Peer-review(s).pdf
Scientific Misconduct Check	66402-Bing-Liu M-2.png
Scientific Editor Work List	66402-Scientific editor work list.pdf