Publication Name	World Journal of Clinical Oncology
Manuscript ID	66689
Country	United States

Received	2021-04-02 02:11
Peer-Review Started	2021-04-02 02:15
To Make the First Decision
Return for Revision	2021-06-07 01:28
Revised	2021-06-14 23:08
Second Decision	2021-08-31 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-31 09:16
Articles in Press	2021-08-31 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-16 05:20
Publish the Manuscript Online	2021-09-17 08:43

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Metastatic disease to the liver: Locoregional therapy strategies and outcomes
Manuscript Source	Invited Manuscript
All Author List	Kylie E Zane, Jordan M Cloyd, Khalid S Mumtaz, Vibhor Wadhwa and Mina S Makary
Funding Agency and Grant Number
Corresponding Author	Mina S Makary, MD, Assistant Professor, Attending Doctor, Director, Department of Radiology, The Ohio State University Wexner Medical Center, 4th Floor Faculty Office Tower, Columbus, OH 43210, United States. mina.makary@osumc.edu
Key Words	Metastatic liver cancer; Transarterial embolization; Chemoembolization; Radioembolization; Ablation; Transarterial chemoembolization; Transarterial radioembolization
Core Tip	Locoregional percutaneous catheter-directed approaches have been associated with better tumor response, improved disease-free and overall survival, and decreased morbidity in metastatic disease to the liver compared to standard treatment1. This review explores recent advances in liver-directed therapies for metastatic liver disease from primary colorectal, neuroendocrine, breast, and lung cancer, as well as uveal melanoma, cholangiocarcinoma, and sarcoma. Therapies discussed include bland transarterial embolization, chemoembolization, radioembolization, and ablative therapies, with a focus on current treatment approaches, outcomes of locoregional therapy, and future directions in each type of metastatic disease.
Publish Date	2021-09-17 08:43
Citation	Zane KE, Cloyd JM, Mumtaz KS, Wadhwa V, Makary MS. Metastatic disease to the liver: Locoregional therapy strategies and outcomes. World J Clin Oncol 2021; 12(9): 725-745
URL	https://www.wjgnet.com/2218-4333/full/v12/i9/725.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i9.725

Full Article (PDF)	WJCO-12-725.pdf
Full Article (Word)	WJCO-12-725.docx
Manuscript File	66689_Auto_Edited-JLW.docx
Answering Reviewers	66689-Answering reviewers.pdf
Audio Core Tip	66689-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66689-Conflict-of-interest statement.pdf
Copyright License Agreement	66689-Copyright license agreement.pdf
Peer-review Report	66689-Peer-review(s).pdf
Scientific Misconduct Check	66689-Scientific misconduct check.pdf
Scientific Editor Work List	66689-Scientific editor work list.pdf