Publication Name	World Journal of Clinical Oncology
Manuscript ID	67207
Country	United Kingdom

Received	2021-04-27 07:10
Peer-Review Started	2021-04-28 12:13
To Make the First Decision
Return for Revision	2021-06-16 04:46
Revised	2021-06-22 14:48
Second Decision	2021-11-25 05:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-28 07:50
Articles in Press	2021-11-28 07:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-15 16:22
Publish the Manuscript Online	2021-12-24 09:38

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Liver regeneration biology: Implications for liver tumour therapies
Manuscript Source	Invited Manuscript
All Author List	Christopher Hadjittofi, Michael Feretis, Jack Martin, Simon Harper and Emmanuel Huguet
Funding Agency and Grant Number
Corresponding Author	Emmanuel Huguet, BSc, DPhil, FRCS, MBChB, Surgeon, Surgical Oncologist, University Department of Surgery, Addenbrookes Hospital, NIHR Comprehensive Biomedical Research and Academic Health Sciences Center, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom. emmanuel.huguet@addenbrookes.nhs.uk
Key Words	Liver; Liver regeneration potential; Regeneration biology; Tumour; Therapies
Core Tip	The liver has remarkable regenerative potential, allowing recovery from 90% hepatectomy in some rodent models. Current understanding of liver regeneration comes from in vitro and animal models. Liver regeneration is controlled by mitogens acting in autocrine, paracrine, and endocrine ways. Complex cross talk occurs between parenchymal and non-parenchymal cells. Regeneration involves hypertrophy and hyperplasia, with both cellular phenotypic fidelity and transdifferentiation, which come into play according to the nature and magnitude of the injury, and the presence of underlying liver disease. Current knowledge provides guiding principles for strategies to optimise liver regeneration potential in the treatment of liver tumours.
Publish Date	2021-12-24 09:38
Citation	Hadjittofi C, Feretis M, Martin J, Harper S, Huguet E. Liver regeneration biology: Implications for liver tumour therapies. World J Clin Oncol 2021; 12(12): 1101-1156
URL	https://www.wjgnet.com/2218-4333/full/v12/i12/1101.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i12.1101

Full Article (PDF)	WJCO-12-1101.pdf
Full Article (Word)	WJCO-12-1101.docx
Manuscript File	67207_Auto_Edited.docx
Answering Reviewers	67207-Answering reviewers.pdf
Audio Core Tip	67207-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67207-Conflict-of-interest statement.pdf
Copyright License Agreement	67207-Copyright license agreement.pdf
Peer-review Report	67207-Peer-review(s).pdf
Scientific Misconduct Check	67207-BIng-Liu M-1.png
Scientific Misconduct Check	67207-BIng-Wu YXJ-2.png
Scientific Editor Work List	67207-Scientific editor work list.pdf