Publication Name	World Journal of Hepatology
Manuscript ID	67327
Country	United Kingdom

Received	2021-04-21 09:26
Peer-Review Started	2021-04-21 09:28
To Make the First Decision
Return for Revision	2021-06-24 07:42
Revised	2021-07-02 10:18
Second Decision	2021-11-16 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-18 06:43
Articles in Press	2021-11-18 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-16 11:06
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Liver function tests and metabolic-associated fatty liver disease: Changes in upper normal limits, does it really matter?
Manuscript Source	Invited Manuscript
All Author List	Roberta Forlano, Benjamin H Mullish, Ameet Dhar, Robert D Goldin, Mark Thursz and Pinelopi Manousou
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London; NIHR Academic Clinical Lectureship CL-2019-21-002 European Association for The Study of the Liver PhD fellowship Juan Rodes 2018
Corresponding Author	Pinelopi Manousou, MD, PhD, Senior Lecturer, Liver Unit/Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Exhibition Road, London W2 1NY, United Kingdom. p.manousou@imperial.ac.uk
Key Words	Metabolic-associated fatty liver disease; Liver function tests; Alanine aminotransferase; Fibrosis; Stiffness
Core Tip	In the United Kingdom, the hepatologists receive increasing demand for secondary care services to investigate liver function tests (LFTs), especially with the suspicion of metabolic-associated fatty liver disease (MAFLD). With current upper normal limit (UNL), patients without liver diseases but elevated LFTs is high (27%), as well as those with significant fibrosis or metabolic-associated steato-hepatitis and normal LFTs (10%). Here, we aimed to evaluate the potential implications of changes in UNL of LFTs. Our data show that reducing the UNL would lead to an increase in overall healthcare burden. In MAFLD, the risk-stratification should rely on a combination of risk factors, rather than on LFTs alone.
Publish Date	2021-12-27 05:24
Citation	Forlano R, Mullish BH, Dhar A, Goldin RD, Thursz M, Manousou P. Liver function tests and metabolic-associated fatty liver disease: Changes in upper normal limits, does it really matter? World J Hepatol 2021; 13(12): 2104-2112
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/2104.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.2104

Full Article (PDF)	WJH-13-2104.pdf
Full Article (Word)	WJH-13-2104.docx
Manuscript File	67327_Auto_Edited.docx
Answering Reviewers	67327-Answering reviewers.pdf
Audio Core Tip	67327-Audio core tip.m4a
Biostatistics Review Certificate	67327-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	67327-Conflict-of-interest statement.pdf
Copyright License Agreement	67327-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67327-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	67327-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	67327-Institutional review board statement.pdf
Supplementary Material	67327-Supplementary material.pdf
Peer-review Report	67327-Peer-review(s).pdf
Scientific Editor Work List	67327-Scientific editor work list.pdf
CrossCheck Report	67327-CrossCheck report.pdf