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12/27/2021 5:43:26 AM | Browse: 318 | Download: 745
Publication Name World Journal of Hepatology
Manuscript ID 67327
Country/Territory United Kingdom
Received
2021-04-21 09:26
Peer-Review Started
2021-04-21 09:28
To Make the First Decision
Return for Revision
2021-06-24 07:42
Revised
2021-07-02 10:18
Second Decision
2021-11-16 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-11-18 06:43
Articles in Press
2021-11-18 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-12-16 11:06
Publish the Manuscript Online
2021-12-27 05:24
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Liver function tests and metabolic-associated fatty liver disease: Changes in upper normal limits, does it really matter?
Manuscript Source Invited Manuscript
All Author List Roberta Forlano, Benjamin H Mullish, Ameet Dhar, Robert D Goldin, Mark Thursz and Pinelopi Manousou
Funding Agency and Grant Number
Funding Agency Grant Number
National Institute of Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London; NIHR Academic Clinical Lectureship CL-2019-21-002
European Association for The Study of the Liver PhD fellowship Juan Rodes 2018
Corresponding Author Pinelopi Manousou, MD, PhD, Senior Lecturer, Liver Unit/Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Exhibition Road, London W2 1NY, United Kingdom. p.manousou@imperial.ac.uk
Key Words Metabolic-associated fatty liver disease; Liver function tests; Alanine aminotransferase; Fibrosis; Stiffness
Core Tip In the United Kingdom, the hepatologists receive increasing demand for secondary care services to investigate liver function tests (LFTs), especially with the suspicion of metabolic-associated fatty liver disease (MAFLD). With current upper normal limit (UNL), patients without liver diseases but elevated LFTs is high (27%), as well as those with significant fibrosis or metabolic-associated steato-hepatitis and normal LFTs (10%). Here, we aimed to evaluate the potential implications of changes in UNL of LFTs. Our data show that reducing the UNL would lead to an increase in overall healthcare burden. In MAFLD, the risk-stratification should rely on a combination of risk factors, rather than on LFTs alone.
Publish Date 2021-12-27 05:24
Citation Forlano R, Mullish BH, Dhar A, Goldin RD, Thursz M, Manousou P. Liver function tests and metabolic-associated fatty liver disease: Changes in upper normal limits, does it really matter? World J Hepatol 2021; 13(12): 2104-2112
URL https://www.wjgnet.com/1948-5182/full/v13/i12/2104.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i12.2104
Full Article (PDF) WJH-13-2104.pdf
Full Article (Word) WJH-13-2104.docx
Manuscript File 67327_Auto_Edited.docx
Answering Reviewers 67327-Answering reviewers.pdf
Audio Core Tip 67327-Audio core tip.m4a
Biostatistics Review Certificate 67327-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 67327-Conflict-of-interest statement.pdf
Copyright License Agreement 67327-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67327-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 67327-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 67327-Institutional review board statement.pdf
Supplementary Material 67327-Supplementary material.pdf
Peer-review Report 67327-Peer-review(s).pdf
Scientific Editor Work List 67327-Scientific editor work list.pdf