Publication Name	World Journal of Gastroenterology
Manuscript ID	67536
Country	Argentina

Received	2021-04-27 19:54
Peer-Review Started	2021-04-27 19:56
To Make the First Decision
Return for Revision	2021-06-13 02:21
Revised	2021-06-26 14:12
Second Decision	2021-08-23 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-23 05:59
Articles in Press	2021-08-23 05:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-09 03:35
Typeset the Manuscript	2021-10-29 08:41
Publish the Manuscript Online	2021-11-06 04:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	María Belén Novoa Díaz, Pedro Matías Carriere, María Julia Martín, Natalia Calvo and Claudia Gentili
Funding Agency and Grant Number	Funding Agency Grant Number Agencia Nacional de Promoción Científica y Tecnológica PICT-2013-1441 Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220150100350 Instituto Nacional del Cáncer (Asistencia financiera II) 12002-4395-14-1 Instituto Nacional del Cáncer (Asistencia financiera III) RESOL-2016-1006-E-APN-MS Universidad Nacional del Sur PGI: 24/B230; PGI: 24/B303
Corresponding Author	Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar
Key Words	Parathyroid hormone-related protein; Colorectal cancer; Tumor biomarkers; Neoplastic processes; Drug resistance; Tumor microenvironment
Core Tip	In colorectal cancer (CRC) cells, we found that parathyroid hormone-related peptide (PTHrP) promotes survival, cell cycle progression, proliferation, migration, chemoresistance and also modulates markers expression associated with invasion, angiogenesis, epithelial to mesenchymal transition and cancer stem cells features. In vivo tests indicate that PTHrP administration increases the expression of several markers related to tumorigenic events. Recently we observed that PTHrP influences on tumor microenvironment cells inducing events associated with the progression of CRC. Our project focuses in understanding the biology of CRC and the underlying mechanisms related to the aggressive behavior of CRC cells with the aim to identify new markers that improve the diagnosis, prognosis and therapy of CRC.
Publish Date	2021-11-06 04:43
Citation	Novoa Díaz MB, Carriere PM, Martín MJ, Calvo N, Gentili C. Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells. World J Gastroenterol 2021; 27(41): 7025-7040
URL	https://www.wjgnet.com/1007-9327/full/v27/i41/7025.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i41.7025

Full Article (PDF)	WJG-27-7025.pdf
Full Article (Word)	WJG-27-7025.docx
Manuscript File	67536-Review-Filipodia-CL.docx
Answering Reviewers	67536-Answering reviewers.pdf
Audio Core Tip	67536-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	67536-Conflict-of-interest statement.pdf
Copyright License Agreement	67536-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67536-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	67536-Language certificate.pdf
Peer-review Report	67536-Peer-review(s).pdf
Scientific Misconduct Check	67536-BIng-Liu M-1.png
Scientific Misconduct Check	67536-Bing-Wu YXJ-2.jpg
Scientific Misconduct Check	67536-Scientific misconduct check.pdf
Scientific Editor Work List	67536-Scientific editor work list.pdf