BPG is committed to discovery and dissemination of knowledge
Featured Articles
12/3/2021 8:02:46 AM | Browse: 271 | Download: 367
Publication Name World Journal of Gastroenterology
Manuscript ID 67566
Country/Territory Italy
Received
2021-04-27 08:05
Peer-Review Started
2021-04-27 08:07
To Make the First Decision
Return for Revision
2021-06-13 03:55
Revised
2021-06-25 15:25
Second Decision
2021-11-19 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-11-21 19:56
Articles in Press
2021-11-21 19:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-24 23:35
Publish the Manuscript Online
2021-12-03 07:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Frontier
Article Title Chronic rejection after liver transplantation: Opening the Pandora’s box
Manuscript Source Invited Manuscript
All Author List Roberta Angelico, Bruno Sensi, Tommaso M Manzia, Giuseppe Tisone, Giuseppe Grassi, Alessandro Signorello, Martina Milana, Ilaria Lenci and Leonardo Baiocchi
Funding Agency and Grant Number
Corresponding Author Leonardo Baiocchi, MD, PhD, Associate Professor, Hepatology Unit, University of Tor Vergata, Viale Oxford 81, Rome 00100, Italy. baiocchi@uniroma2.it
Key Words Liver transplantation; Chronic rejection; Immunosuppression; T cell-mediated rejection; Antibody-mediated rejection; Donor-specific antibody; Re-transplantation; Graft loss; Complications; Outcomes
Core Tip Chronic rejection (CR) still represents a cause of graft loss after liver transplantation. Recent advances in understanding the pathways leading to CR, through a T cell-mediated or antibody mediated injury, are opening new strategies for its management. Early detection of CR, tailored immunosuppressive regimen and strict monitoring are essential to prevent graft loss rejection-related requiring re-transplantation. The current perspectives aim to identify non-invasive biomarkers predicting patients at risk for CR in order to prevent irreversible liver damage by adequate immunosuppressive regimen and improving long-term outcomes after liver transplantation.
Publish Date 2021-12-03 07:34
Citation Angelico R, Sensi B, Manzia TM, Tisone G, Grassi G, Signorello A, Milana M, Lenci I, Baiocchi L. Chronic rejection after liver transplantation: Opening the Pandora’s box. World J Gastroenterol 2021; 27(45): 7771-7783
URL https://www.wjgnet.com/1007-9327/full/v27/i45/7771.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i45.7771
Full Article (PDF) WJG-27-7771.pdf
Full Article (Word) WJG-27-7771.docx
Manuscript File 67566_Auto_Edited.docx
Answering Reviewers 67566-Answering reviewers.pdf
Audio Core Tip 67566-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 67566-Conflict-of-interest statement.pdf
Copyright License Agreement 67566-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 67566-Language certificate.pdf
Peer-review Report 67566-Peer-review(s).pdf
Scientific Misconduct Check 67566-Bing-Liu M-1.png
Scientific Misconduct Check 67566-Bing-Wu XYJ-2.png
Scientific Editor Work List 67566-Scientific editor work list.pdf