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12/24/2021 9:55:41 AM | Browse: 274 | Download: 605
Publication Name World Journal of Gastroenterology
Manuscript ID 67569
Country/Territory China
Received
2021-04-27 11:05
Peer-Review Started
2021-04-27 11:07
To Make the First Decision
Return for Revision
2021-06-13 03:47
Revised
2021-06-22 08:36
Second Decision
2021-12-10 06:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-10 22:57
Articles in Press
2021-12-10 22:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-10-27 08:01
Typeset the Manuscript
2021-12-17 04:02
Publish the Manuscript Online
2021-12-24 09:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Xiao-Cui Wei, Ya-Ru Xia, Ping Zhou, Xing Xue, Li-Juan Liu, Shuang Ding and Fan Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81971943
the Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University TFJC 2018002
National Natural Science Foundation of China 81772196
Corresponding Author Fan Zhu, PhD, Professor, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Medical Microbiology, School of Medicine, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Key Words Hepatocellular carcinoma; Exosomes; miR-135a-5p; Anti-apoptosis; Proliferation; Chemoresistance
Core Tip Hepatitis B virus infection is the most common cause of hepatocellular carcinoma (HCC). Drug resistance is the primary reason for the high mortality of HCC patients. We demonstrated that hepatitis B core antigen (HBc) increased exosomal miR-135a-5p. Tissue samples showed that the level of miR-135a-5p was significantly elevated in HCC tissues. Vesicle-associated membrane protein 2 (VAMP2) was demonstrated to be a target gene of miR-135a-5p. Further investigation recommended that HBc enhanced the anti-apoptosis, cell proliferation, and chemotherapy resistance of HCC cells through exosomal miR-135a-5p by targeting VAMP2. Our findings reveal that HBc can cause anti-cancer drug resistance in HCC and provide us with a novel mechanism underlying drug resistance in cancer chemotherapy.
Publish Date 2021-12-24 09:48
Citation Wei XC, Xia YR, Zhou P, Xue X, Ding S, Liu LJ, Zhu F. Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma. World J Gastroenterol 2021; 27(48): 8302-8322
URL https://www.wjgnet.com/1007-9327/full/v27/i48/8302.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i48.8302
Full Article (PDF) WJG-27-8302.pdf
Full Article (Word) WJG-27-8302.docx
Manuscript File 67569_Auto_Edited-YXJW-Webster J.docx
Answering Reviewers 67569-Answering reviewers.pdf
Audio Core Tip 67569-Audio core tip.m4a
Biostatistics Review Certificate 67569-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 67569-Conflict-of-interest statement.pdf
Copyright License Agreement 67569-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67569-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 67569-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 67569-Language certificate.pdf
Supplementary Material 67569-Supplementary material.pdf
Peer-review Report 67569-Peer-review(s).pdf
Scientific Misconduct Check 67569-Bing-Liu M-1.png
Scientific Misconduct Check 67569-Bing-Wu YXJ-2.jpg