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8/20/2021 10:19:34 AM | Browse: 380 | Download: 1146
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Received |
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2021-05-11 10:00 |
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Peer-Review Started |
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2021-05-11 10:03 |
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To Make the First Decision |
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Return for Revision |
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2021-06-24 02:13 |
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Revised |
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2021-07-07 21:44 |
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Second Decision |
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2021-07-14 03:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-14 09:47 |
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Articles in Press |
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2021-07-14 09:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-22 04:36 |
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Typeset the Manuscript |
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2021-08-16 07:13 |
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Publish the Manuscript Online |
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2021-08-20 09:33 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ali Madian, Ahmed Eliwa, Hytham Abdalla and Haitham A Azeem Aly |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ali Madian, MD, MSc, Lecturer, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Al-Azhar University-Assiut, Al Walideyah Al Bahreyah, Assiut 71524, EG, Egypt. a.madian@azhar.edu.eg |
| Key Words |
COVID-19; Liver injury; Aspartate amino transferase; All-cause in-hospital mortality; Serum ferritin; SARS-CoV-2 |
| Core Tip |
Liver injury with an aspartate transferase (AST)-dominant pattern can be used to predict the severity of coronavirus disease 2019 (COVID-19). A one-fold increase in the serum AST level increases the odds of in-hospital mortality by eleven-fold compared with individuals with normal AST levels. Moreover, a two-fold increase in the serum AST levels increases the odds of mortality by thirteen-fold. Moreover, our study confirmed an elevated level of ferritin in patients with COVID-19. Increased ferritin levels are associated with fatal outcomes. Meticulous monitoring is highly recommended for patients with COVID-19 presenting AST-dominant hepatocellular injury, especially those older than 60 years, those with elevated ferritin levels or those with diabetes mellitus. |
| Publish Date |
2021-08-20 09:33 |
| Citation |
Madian A, Eliwa A, Abdalla H, Aly HAA. Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study. World J Hepatol 2021; 13(8): 939-948 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i8/939.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i8.939 |
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