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11/19/2021 11:47:26 AM | Browse: 67 | Download: 49
Publication Name World Journal of Gastroenterology
Manuscript ID 68446
Country/Territory China
Received
2021-05-23 15:40
Peer-Review Started
2021-05-23 15:43
To Make the First Decision
Return for Revision
2021-06-12 02:24
Revised
2021-07-19 11:04
Second Decision
2021-10-26 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-27 03:04
Articles in Press
2021-10-27 03:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-10-06 11:14
Typeset the Manuscript
2021-11-16 14:16
Publish the Manuscript Online
2021-11-19 11:15
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Survivin-positive circulating tumor cells as a marker for metastasis of hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jing Yu, Zhan Wang, Hua Zhang, Yi Wang and Dong-Qing Li
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of China 81772839
Health and Family Planning Commission Foundation of Hubei Province WJ2019H194
Corresponding Author Jing Yu, PhD, Associate Chief Technician, Doctor, Blood Transfusion Department, Wuhan Chinese and Western Medicine Hospital, No. 215 Zhongshan road, Wuhan 430022, Hubei Province, China. yujings9774@sina.com.cn
Key Words Survivin; Circulating tumor cells; Hepatocellular carcinoma; Prognosis; Metastasis
Core Tip This study first analyzed the circulating tumor cell (CTC)-survivin positive in patients with hepatocellular carcinoma (HCC). The signal levels of survivin expression in different CTCs were significant different. The rates of moderate and high signal in the mesenchymal and hybrid CTCs were significant more than those in the epithelial CTCs. Survivin overexpression induces HCC cells proliferation, invasive ability and reduce apoptosis. The expression of survivin in mesenchymal CTCs (mCTCs) in liver cancer is associated with metastasis and detection of survivin positivity in mCTCs may have a potential value in early detection of tumor metastases and prognostic evaluation.
Publish Date 2021-11-19 11:15
Citation Yu J, Wang Z, Zhang H, Wang Y, Li DQ. Survivin-positive circulating tumor cells as a marker of the metastasis of hepatocellular carcinoma. World J Gastroenterol 2021; 27(43): 7546-7562
URL https://www.wjgnet.com/1007-9327/full/v27/i43/7546.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i43.7546
Full Article (PDF) WJG-27-7546.pdf
Full Article (Word) WJG-27-7546.docx
Manuscript File 68446_Auto_Edited-ML-WangTQ-pdf.docx
Answering Reviewers 68446-Answering reviewers.pdf
Audio Core Tip 68446-Audio core tip.m4a
Biostatistics Review Certificate 68446-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 68446-Conflict-of-interest statement.pdf
Copyright License Agreement 68446-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 68446-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 68446-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 68446-Language certificate.pdf
Supplementary Material 68446-Supplementary material.pdf
Peer-review Report 68446-Peer-review(s).pdf
Scientific Misconduct Check 68446-Bing-Liu M-2.png
Scientific Editor Work List 68446-Scientific editor work list.pdf