Publication Name	World Journal of Hepatology
Manuscript ID	68483
Country	India

Received	2021-05-24 17:26
Peer-Review Started	2021-05-24 17:27
To Make the First Decision
Return for Revision	2021-06-15 18:18
Revised	2021-06-30 11:08
Second Decision	2021-08-17 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-18 06:41
Articles in Press	2021-08-18 06:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-31 04:03
Typeset the Manuscript	2021-11-19 00:40
Publish the Manuscript Online	2021-11-24 09:54

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’
Manuscript Source	Invited Manuscript
All Author List	Amrit Gopan and Moinak S Sarma
Funding Agency and Grant Number
Corresponding Author	Moinak S Sarma, N/A, Associate Professor, DM, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, India. moinaksen@yahoo.com
Key Words	Mitochondrial hepatopathy; Respiratory chain defects; Maternal inheritance; Neonatal liver failure; DNA depletion syndrome; Pearson syndrome
Core Tip	Liver disease with multi-system involvement should arouse the suspicion for mitochondrial respiratory chain hepatopathies. These disorders are predominantly autosomal recessive with some having a maternal inheritance. Presence of lactic acidosis without hypoglycemia is an important clue. A tiered evaluation yields the most with final step being a genetic and enzyme analysis from tissue of interest. Treatment is largely supportive with blood transfusions, correction of acidosis, shock, providing cofactors and salvage therapies, with liver transplantation in a select group. A Periodic follow-up is mandatory for monitoring evolution of disease including “migration” to other systems.
Publish Date	2021-11-24 09:54
Citation	Gopan A, Sarma MS. Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’. World J Hepatol 2021; 13(11): 1707-1726
URL	https://www.wjgnet.com/1948-5182/full/v13/i11/1707.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i11.1707

Full Article (PDF)	WJH-13-1707.pdf
Full Article (Word)	WJH-13-1707.docx
Manuscript File	68483-Review-Filipodia-CL.docx
Answering Reviewers	68483-Answering reviewers.pdf
Audio Core Tip	68483-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	68483-Conflict-of-interest statement.pdf
Copyright License Agreement	68483-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68483-Language certificate.pdf
Peer-review Report	68483-Peer-review(s).pdf
Scientific Misconduct Check	68483-Bing-Gao CC-1.jpg
Scientific Misconduct Check	68483-Bing-Wang JJ-2.jpg
Scientific Misconduct Check	68483-Scientific misconduct check.pdf
Scientific Editor Work List	68483-Scientific editor work list.pdf