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1/12/2022 6:08:58 AM | Browse: 31 | Download: 62
Publication Name World Journal of Clinical Cases
Manuscript ID 69610
Country/Territory China
Received
2021-07-09 13:37
Peer-Review Started
2021-07-09 13:42
To Make the First Decision
Return for Revision
2021-11-11 03:05
Revised
2021-11-19 08:54
Second Decision
2021-12-06 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-08 05:07
Articles in Press
2021-12-08 05:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-03 11:14
Publish the Manuscript Online
2022-01-12 04:01
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Retrospective Study
Article Title N6-methyladenine-modified DNA was decreased in Alzheimer’s disease patients
Manuscript Source Unsolicited Manuscript
All Author List Shuang Lv, Xiao Zhou, Yi-Ming Li, Tao Yang, Shu-Juan Zhang, Yu Wang, Shu-Hong Jia and Dan-Tao Peng
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R&D Program of China 2016YFC1306300
National Natural Science Foundation of China 81974220
Corresponding Author Dan-Tao Peng, PhD, Chief Physician, Professor, Department of Neurology, China-Japan Friendship Hospital, No.2 Yinghuayuandong Street, Beijing 100029, China. pengdantao2000@163.com
Key Words Alzheimer disease; N6-methyladenine; DNA; Montreal Cognitive Assessment; Apolipoprotein E; Cognitive dysfunction
Core Tip Although Alzheimer’s disease (AD) cannot be cured, early diagnosis and treatment can greatly improve the prognosis of AD patients. Thus, we aimed to identify biomarkers of AD that can be useful in the clinic. The diagnostic criteria for AD were strictly employed in the study. We found that N6-methyladenine (m6A) DNA adenine methylation may be a novel biomarker of AD. Twenty subjects underwent 18F-AV-45 (florbetapir) positron emission tomography to test this assertion. In addition, the global m6A DNA methylation level was also correlated with cognition level.
Publish Date 2022-01-12 04:01
Citation Lv S, Zhou X, Li YM, Yang T, Zhang SJ, Wang Y, Jia SH, Peng DT. N6-methyladenine-modified DNA was decreased in Alzheimer’s disease patients. World J Clin Cases 2022; 10(2): 448-457
URL https://www.wjgnet.com/2307-8960/full/v10/i2/448.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i2.448
Full Article (PDF) WJCC-10-448.pdf
Full Article (Word) WJCC-10-448.docx
Manuscript File 69610_Auto_Edited.docx
Answering Reviewers 69610-Answering reviewers.pdf
Audio Core Tip 69610-Audio core tip.aac
Biostatistics Review Certificate 69610-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69610-Conflict-of-interest statement.pdf
Copyright License Agreement 69610-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 69610-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 69610-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 69610-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 69610-Language certificate.pdf
Peer-review Report 69610-Peer-review(s).pdf
Scientific Misconduct Check 69610-Bing-Wu YXJ-2.png
Scientific Editor Work List 69610-Scientific editor work list.pdf