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11/17/2021 2:32:04 AM | Browse: 271 | Download: 713
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Received |
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2021-07-08 02:01 |
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Peer-Review Started |
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2021-07-08 02:06 |
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To Make the First Decision |
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Return for Revision |
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2021-07-28 21:33 |
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Revised |
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2021-08-05 08:57 |
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Second Decision |
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2021-09-22 03:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-09-23 07:24 |
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Articles in Press |
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2021-09-23 07:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-12 05:58 |
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Publish the Manuscript Online |
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2021-11-17 02:18 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Subgrouping time-dependent prescribing patterns of first-onset major depressive episodes by psychotropics dissection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hsi-Chung Chen, Hui-Hsuan Hsu, Mong-Liang Lu, Ming-Chyi Huang, Chun-Hsin Chen, Tzu-Hua Wu, Wei-Chung Mao, Chuhsing K Hsiao and Po-Hsiu Kuo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Ministry of Science and Technology, Taiwan |
MOST 107-2314-B-002-219 |
| the Ministry of Science and Technology, Taiwan |
MOST 108-2314-B-002-110-MY2 |
| he National Taiwan University Hospital |
UN110-021 |
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| Corresponding Author |
Po-Hsiu Kuo, PhD, Professor, Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Rm 521, No. 17, Xuzhou Road, Taipei 100, Taiwan. phkuo@ntu.edu.tw |
| Key Words |
First episode; Depression; Classification; Psychopharmacology; Depression treatment |
| Core Tip |
This study evaluated the time-dependent prescription patterns in drug-naive patients experiencing their first major depressive episode with data collected over the first 2 years after disease onset. The K-means clustering analysis was performed, along with the evaluation of four input parameters to generate data-based subgroups. Four feature-based clusters were identified, differentiated by the time-dependent prescription profiles and burden of the disease. Our novel parameters successfully captured the reciprocal interaction between physicians' prescriptions and disease status in a real-world setting. This study presents a novel clustering strategy that can be used to generate prescription-based subtypes. |
| Publish Date |
2021-11-17 02:18 |
| Citation |
Chen HC, Hsu HH, Lu ML, Huang MC, Chen CH, Wu TH, Mao WC, Hsiao CK, Kuo PH. Subgrouping time-dependent prescribing patterns of first-onset major depressive episodes by psychotropics dissection. World J Psychiatr 2021; 11(11): 1116-1128 |
| URL |
https://www.wjgnet.com/2220-3206/full/v11/i11/1116.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v11.i11.1116 |
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