Publication Name	World Journal of Psychiatry
Manuscript ID	69758
Country	Thailand

Received	2021-07-11 07:09
Peer-Review Started	2021-07-11 07:15
To Make the First Decision
Return for Revision	2021-10-04 00:50
Revised	2021-10-07 07:48
Second Decision	2022-04-21 02:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-04-26 05:34
Articles in Press	2022-04-26 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-04 22:28
Typeset the Manuscript	2022-04-28 08:03
Publish the Manuscript Online	2022-05-18 06:40

ISSN	2220-3206 (online)
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Category	Neurosciences
Manuscript Type	Opinion Review
Article Title	False dogmas in mood disorders research: Towards a nomothetic network approach
Manuscript Source	Invited Manuscript
All Author List	Michael HJ Maes and Drozdstoy Stoyanov
Funding Agency and Grant Number	Funding Agency Grant Number Ratchadapiseksompotch Funds, Faculty of Medicine, Chulalongkorn University RA61/050
Corresponding Author	Michael HJ Maes, PhD, Professor, Department of Psychiatry, Chulalongkorn University, Rama IV, Bangkok 10330, Thailand. dr.michaelmaes@hotmail.com
Key Words	Nomothetic network psychiatry; Depression; Mood disorders; Affective disorders; Inflammation; Oxidative and nitrosative stress; Neuro-immune
Core Tip	We review the merits of machine learning-derived nomothetic network psychiatry (NNP) models of mood disorders. The NNP models of mood disorders show that major depressive disorder/bipolar disorder are not mind-brain or psycho-social but systemic medical disorders. The DSM/ICD taxonomies are counterproductive. A shared core, namely the reoccurrence of illness (ROI), underpins the intertwined recurrence of depressive and manic episodes and suicidal behaviors. Mood disorders should be ROI-defined. ROI mediates the effects of nitro-oxidative stress pathways and early lifetime trauma on the phenome of mood disorders. Severity of illness and treatment response should be delineated using NNP-derived causome, adverse outcome pathways, ROI and phenome scores.
Publish Date	2022-05-18 06:40
Citation	Maes MH, Stoyanov D. False dogmas in mood disorders research: Towards a nomothetic network approach. World J Psychiatry 2022; 12(5): 651-667
URL	https://www.wjgnet.com/2220-3206/full/v12/i5/651.htm
DOI	https://dx.doi.org/10.5498/wjp.v12.i5.651

Full Article (PDF)	WJP-12-651.pdf
Full Article (Word)	WJP-12-651.docx
Manuscript File	69758_Auto_Edited_LM.docx
Answering Reviewers	69758-Answering reviewers.pdf
Audio Core Tip	69758-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69758-Conflict-of-interest statement.pdf
Copyright License Agreement	69758-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	69758-Grant application form(s).pdf
Peer-review Report	69758-Peer-review(s).pdf
Scientific Misconduct Check	69758-Bing-Wang JJ-2.png
Scientific Editor Work List	69758-Scientific editor work list.pdf
CrossCheck Report	69758-CrossCheck report.pdf