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12/31/2021 12:21:59 PM | Browse: 298 | Download: 599
Publication Name World Journal of Gastroenterology
Manuscript ID 69859
Country/Territory China
Received
2021-07-14 00:49
Peer-Review Started
2021-07-14 00:54
To Make the First Decision
Return for Revision
2021-10-03 07:06
Revised
2021-10-22 17:48
Second Decision
2021-12-13 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-22 23:30
Articles in Press
2021-12-22 23:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-12-29 14:52
Publish the Manuscript Online
2021-12-31 12:21
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway
Manuscript Source Unsolicited Manuscript
All Author List Tao Huang, Yuan-Qing-Xiao Li, Ming-Yu Zhou, Rui-Han Hu, Gao-Liang Zou, Jian-Chao Li, Shu Feng, Yong-Mei Liu, Chang-Qin Xin and Xue-Ke Zhao
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 81860115
National Natural Science Foundation of China (General Program) 82060116
National Natural Science Foundation of China (General Program) 81960118
Science and Technology Support Project of Guizhou Province No.[2021]094
Corresponding Author Xue-Ke Zhao, PhD, Professor, infectious diseases , affiliated hospital of guizhou medical university, 9th Beijing Road, Guiyang 550004, China. zhaoxueke1@163.com
Key Words Liver fibrosis; Hepatic stellate cells; Focal adhesion kinase; Focal adhesion kinase-related non-kinase; Aerobic glycolysis; Enolase1
Core Tip We show that focal adhesion kinase-related non-kinase (FRNK) limits hepatic stellate cell (HSC) activation, proliferation, and migration and promotes HSC apoptosis by inhibiting aerobic glycolysis, thereby ameliorating liver fibrosis. FRNK may represent a potential therapeutic candidate for liver fibrosis treatment.
Publish Date 2021-12-31 12:21
Citation Huang T, Li YQX, Zhou MY, Hu RH, Zou GL, Li JC, Feng S, Liu YM, Xin CQ, Zhao XK. Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway. World J Gastroenterol 2022; 28(1): 123-139
URL https://www.wjgnet.com/1007-9327/full/v28/i1/123.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i1.123
Full Article (PDF) WJG-28-123.pdf
Full Article (Word) WJG-28-123.docx
The ARRIVE Guidelines 69859-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 69859_Auto_Edited.docx
Answering Reviewers 69859-Answering reviewers.pdf
Audio Core Tip 69859-Audio core tip.m4a
Biostatistics Review Certificate 69859-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69859-Conflict-of-interest statement.pdf
Copyright License Agreement 69859-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 69859-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 69859-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 69859-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 69859-Language certificate.pdf
Supplementary Material 69859-Supplementary material.pdf
Peer-review Report 69859-Peer-review(s).pdf
Scientific Misconduct Check 69859-Bing-Wang LL-2.png
Scientific Editor Work List 69859-Scientific editor work list.pdf