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6/22/2022 11:51:54 AM | Browse: 21 | Download: 70
Publication Name World Journal of Clinical Oncology
Manuscript ID 70622
Country/Territory Brazil
2021-08-08 22:30
Peer-Review Started
2021-08-08 22:31
To Make the First Decision
Return for Revision
2021-09-02 02:11
2021-09-16 22:31
Second Decision
2022-05-23 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-28 07:18
Articles in Press
2022-05-28 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-05-31 03:00
Publish the Manuscript Online
2022-06-22 08:29
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development
Manuscript Source Invited Manuscript
All Author List Vítor Hugo Sales da Mota, Fabrício Freire de Melo, Breno Bittencourt de Brito, Filipe Antônio França da Silva and Kádima Nayara Teixeira
Funding Agency and Grant Number
Corresponding Author Kádima Nayara Teixeira, PhD, Adjunct Professor, Campus Toledo, Universidade Federal do Paraná, Road 182, km 320/321, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Key Words DS-3032B; Mouse double minute 2 antagonist; Molecular docking; Tumor suppressor p53
Core Tip The knowledge, at the molecular level, of the complexes formed by therapeutic drugs and their target in the body are relevant to understand the efficiency of the drug. These data can be provided, with high reliability, by bioinformatics tools, which saves time in relation to in vitro and in vivo analyses. The drug DS-3032B has been a potential candidate for oncogenic treatment in preclinical trials, but clinical studies are scarce. This work shows data on chemical interactions between this drug and its target, mouse double minute 2, that corroborate the preclinical data and demonstrate the stability of the therapeutic complex.
Publish Date 2022-06-22 08:29
Citation da Mota VHS, Freire de Melo F, de Brito BB, Silva FAFD, Teixeira KN. Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development. World J Clin Oncol 2022; 13(6): 496-504
URL https://www.wjgnet.com/2218-4333/full/v13/i6/496.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i6.496
Full Article (PDF) WJCO-13-496.pdf
Full Article (Word) WJCO-13-496.docx
Manuscript File 70622_Auto_Edited-ZMG-FilipodiaCL-LS.docx
Answering Reviewers 70622-Answering reviewers.pdf
Audio Core Tip 70622-Audio core tip.mpeg
Biostatistics Review Certificate 70622-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 70622-Conflict-of-interest statement.pdf
Copyright License Agreement 70622-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 70622-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 70622-Language certificate.pdf
Peer-review Report 70622-Peer-review(s).pdf
Scientific Misconduct Check 70622-CrossCheck.jpg
Scientific Misconduct Check 70622-Bing-Gong ZM-2.jpg
Scientific Editor Work List 70622-Scientific editor work list.pdf