Publication Name	World Journal of Clinical Oncology
Manuscript ID	70622
Country	Brazil

Received	2021-08-08 22:30
Peer-Review Started	2021-08-08 22:31
To Make the First Decision
Return for Revision	2021-09-02 02:11
Revised	2021-09-16 22:31
Second Decision	2022-05-23 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-28 07:18
Articles in Press	2022-05-28 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-31 03:00
Publish the Manuscript Online	2022-06-22 08:29

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development
Manuscript Source	Invited Manuscript
All Author List	Vítor Hugo Sales da Mota, Fabrício Freire de Melo, Breno Bittencourt de Brito, Filipe Antônio França da Silva and Kádima Nayara Teixeira
Funding Agency and Grant Number
Corresponding Author	Kádima Nayara Teixeira, PhD, Adjunct Professor, Campus Toledo, Universidade Federal do Paraná, Road 182, km 320/321, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Key Words	DS-3032B; Mouse double minute 2 antagonist; Molecular docking; Tumor suppressor p53
Core Tip	The knowledge, at the molecular level, of the complexes formed by therapeutic drugs and their target in the body are relevant to understand the efficiency of the drug. These data can be provided, with high reliability, by bioinformatics tools, which saves time in relation to in vitro and in vivo analyses. The drug DS-3032B has been a potential candidate for oncogenic treatment in preclinical trials, but clinical studies are scarce. This work shows data on chemical interactions between this drug and its target, mouse double minute 2, that corroborate the preclinical data and demonstrate the stability of the therapeutic complex.
Publish Date	2022-06-22 08:29
Citation	da Mota VHS, Freire de Melo F, de Brito BB, Silva FAFD, Teixeira KN. Molecular docking of DS-3032B, a mouse double minute 2 enzyme antagonist with potential for oncology treatment development. World J Clin Oncol 2022; 13(6): 496-504
URL	https://www.wjgnet.com/2218-4333/full/v13/i6/496.htm
DOI	https://dx.doi.org/10.5306/wjco.v13.i6.496

Full Article (PDF)	WJCO-13-496.pdf
Full Article (Word)	WJCO-13-496.docx
Manuscript File	70622_Auto_Edited-ZMG-FilipodiaCL-LS.docx
Answering Reviewers	70622-Answering reviewers.pdf
Audio Core Tip	70622-Audio core tip.mpeg
Biostatistics Review Certificate	70622-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	70622-Conflict-of-interest statement.pdf
Copyright License Agreement	70622-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	70622-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70622-Language certificate.pdf
Peer-review Report	70622-Peer-review(s).pdf
Scientific Misconduct Check	70622-CrossCheck.jpg
Scientific Misconduct Check	70622-Bing-Gong ZM-2.jpg
Scientific Editor Work List	70622-Scientific editor work list.pdf