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3/11/2022 9:50:18 AM | Browse: 189 | Download: 395
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Received |
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2021-08-22 20:23 |
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Peer-Review Started |
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2021-08-22 20:27 |
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To Make the First Decision |
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Return for Revision |
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2021-09-12 16:16 |
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Revised |
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2021-10-08 18:42 |
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Second Decision |
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2022-01-25 03:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-01-26 22:20 |
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Articles in Press |
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2022-01-26 22:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-03-07 07:56 |
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Publish the Manuscript Online |
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2022-03-11 09:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cristina M Hagen, Eva Roth, Theresia Reding Graf, François Verrey, Rolf Graf, Anurag Gupta, Giovanni Pellegrini, Nadège Poncet and Simone Mafalda Rodrigues Camargo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Simone Mafalda Rodrigues Camargo, PhD, Pharmacist, Senior Scientist, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, ZH, Switzerland. simone.camargo@physiol.uzh.ch |
| Key Words |
Acute pancreatitis; Amino acid transporter; LAT1; Metabolism; Regeneration; Fibrosis |
| Core Tip |
LAT1 (slc7a5) transports amino acids into cells and is an upstream regulator of metabolic signaling pathways. This transporter was shown to play an important role in highly proliferative cells during embryonic development and cancer, controlling protein synthesis and cell proliferation. In this study we provide evidence that LAT1 plays a role in the pancreatic acinar regeneration after acute pancreatitis. Additionally, knocking down LAT1 revealed a sex difference in the regenerative process, which may be supportive to understand gender differences in the clinical setting. |
| Publish Date |
2022-03-11 09:47 |
| Citation |
Hagen CM, Roth E, Graf TR, Verrey F, Graf R, Gupta A, Pellegrini G, Poncet N, Camargo SMR. Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis. World J Gastroenterol 2022; 28(10): 1024-1054 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i10/1024.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i10.1024 |
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