Publication Name	World Journal of Orthopedics
Manuscript ID	71001
Country	United Kingdom

Received	2021-08-23 10:47
Peer-Review Started	2021-08-26 23:58
To Make the First Decision
Return for Revision	2021-11-17 08:00
Revised	2021-12-01 22:02
Second Decision	2022-10-25 03:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-10-28 18:08
Articles in Press	2022-10-28 18:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-26 09:09
Typeset the Manuscript	2022-10-31 06:58
Publish the Manuscript Online	2022-11-16 11:29

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Viral infections in orthopedics: A systematic review and classification proposal
Manuscript Source	Invited Manuscript
All Author List	Konstantinos Sidiropoulos, Savvas Ilias Christofilos, Konstantinos Tsikopoulos, Dimitrios Kitridis, Lorenzo Drago, Gabriele Meroni, Carlo Luca Romanò and Venu Kavarthapu
Funding Agency and Grant Number
Corresponding Author	Savvas Ilias Christofilos, MD, Doctor, Genetics, Evolution and Environment, University College London, Piazzale Aldo Moro 5, London WC1E 6BT, United Kingdom. savvaschristofilos@gmail.com
Key Words	Viral infection; Musculoskeletal system; Bone and joint manifestations; Chikungunya; Zika; Hepatitis C virus; Herpesviridae; Ross River virus; Cross-reactivity; Classification
Core Tip	Viral infections can include multiple orthopedic manifestations, thus resulting in significant distress. In addition, the outcome of orthopedic surgeries may be influenced by certain chronic viral infections such as hepatitis C virus. There is evidence of autoimmune-mediated mechanisms, immunosuppression, and perhaps direct viral infection provoking this, although the precise mechanisms have yet to be fully understood. In this review, a classification scheme was proposed. However, further research is needed to unveil the relative contributions of the identified mechanisms and develop novel preventative and treatment strategies.
Publish Date	2022-11-16 11:29
Citation	Sidiropoulos K, Christofilos SI, Tsikopoulos K, Kitridis D, Drago L, Meroni G, Romanò CL, Kavarthapu V. Viral infections in orthopedics: A systematic review and classification proposal. World J Orthop 2022; 13(11): 1015-1028
URL	https://www.wjgnet.com/2218-5836/full/v13/i11/1015.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i11.1015

Full Article (PDF)	WJO-13-1015.pdf
Full Article (Word)	WJO-13-1015.docx
Manuscript File	71001_Auto_Edited-LM.docx
Answering Reviewers	71001-Answering reviewers.pdf
Audio Core Tip	71001-Audio core tip.m4a
Biostatistics Review Certificate	71001-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	71001-Conflict-of-interest statement.pdf
Copyright License Agreement	71001-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	71001-Language certificate.pdf
Supplementary Material	71001-Supplementary material.pdf
Peer-review Report	71001-Peer-review(s).pdf
Scientific Misconduct Check	71001-Bing-Wu YXJ-2.png
Scientific Editor Work List	71001-Scientific editor work list.pdf