Publication Name	World Journal of Diabetes
Manuscript ID	71184
Country	Greece

Received	2021-08-30 04:16
Peer-Review Started	2021-08-30 04:18
To Make the First Decision
Return for Revision	2021-10-03 19:09
Revised	2021-10-24 04:41
Second Decision	2022-02-21 07:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-23 20:56
Articles in Press	2022-02-23 20:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-08 17:58
Publish the Manuscript Online	2022-03-15 14:23

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Humanin and diabetes mellitus: A review of in vitro and in vivo studies
Manuscript Source	Invited Manuscript
All Author List	Chrysoula Boutari, Panagiotis D Pappas, Theodoros D Theodoridis and Dimitrios Vavilis
Funding Agency and Grant Number
Corresponding Author	Chrysoula Boutari, MD, MSc, PhD, Manager, Doctor, Doctor, Instructor, Postdoc, Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, 49, Konstantinoupoleos Street, Thessaloniki 54642, Greece. chrisoulabgr@yahoo.gr
Key Words	Diabetes mellitus; Insulin resistance; Humanin; Aging; Apoptosis; Oxidative stress
Core Tip	Humanin (HN) exerts cyto-protective and anti-apoptotic effects. Type 2 diabetes mellitus (T2DM) is considered an age-related disease. Beyond the role of HN against age-related diseases, it increases insulin sensitivity, improves the survival of pancreatic beta cells, and delays the onset of diabetes. Altered HN levels could serve as a potential biomarker in prediabetes and T2DM, since they seem to be an effect or a response to the increased reactive oxygen species production, oxidative stress, and reduced mitochondrial DNA copy number-A major and important question is whether HN could be used as a potential therapeutic option for diabetes.
Publish Date	2022-03-15 14:23
Citation	Boutari C, Pappas PD, Theodoridis TD, Vavilis D. Humanin and diabetes mellitus: A review of in vitro and in vivo studies. World J Diabetes 2022; 13(3): 213-223
URL	https://www.wjgnet.com/1948-9358/full/v13/i3/213.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i3.213

Full Article (PDF)	WJD-13-213.pdf
Full Article (Word)	WJD-13-213.docx
Manuscript File	71184_Auto_Edited.docx
Answering Reviewers	71184-Answering reviewers.pdf
Audio Core Tip	71184-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	71184-Conflict-of-interest statement.pdf
Copyright License Agreement	71184-Copyright license agreement.pdf
Peer-review Report	71184-Peer-review(s).pdf
Scientific Misconduct Check	71184-Bing-Wang LL-2.png
Scientific Editor Work List	71184-Scientific editor work list.pdf
CrossCheck Report	71184-CrossCheck report.pdf