Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	71285
Country	United States

Received	2021-09-02 13:28
Peer-Review Started	2021-09-02 13:29
To Make the First Decision
Return for Revision	2021-11-22 08:52
Revised	2021-12-03 21:44
Second Decision	2022-02-11 05:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-13 17:06
Articles in Press	2022-02-13 17:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-22 02:03
Publish the Manuscript Online	2022-04-25 09:07

ISSN	2220-3176 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Microbiology
Manuscript Type	Basic Study
Article Title	Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus
Manuscript Source	Unsolicited Manuscript
All Author List	Allison Zank, Lillian Schulte, Xavier Brandon, Lauren Carstensen, Amy Wescott and William R Schwan
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation Graduate Research Program to Zank A 0002016179620
Corresponding Author	William R Schwan, PhD, Professor, Department of Microbiology, University of Wisconsin-La Crosse, 1725 State St, La Crosse, WI 54601, United States. wschwan@uwlax.edu
Key Words	Biofilm; Two-component system; Stilbene; Staphylococcus aureus; Late-stage competence; SK-03-92
Core Tip	Staphylococcus aureus (S. aureus) is a primary cause of skin/soft tissue infections. In this study, we have shown that two previously uncharacterized genes, brpR and brpS, encode proteins that we believe comprise a two-component system that regulates biofilm formation in S. aureus.
Publish Date	2022-04-25 09:07
Citation	Zank A, Schulte L, Brandon X, Carstensen L, Wescott A, Schwan WR. Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus. World J Clin Infect Dis 2022;12(1): 20-32
URL	https://www.wjgnet.com/2220-3176/full/v12/i1/20.htm
DOI	https://dx.doi.org/10.5495/wjcid.v12.i1.20

Full Article (PDF)	WJCID-12-20.pdf
Full Article (Word)	WJCID-12-20.docx
Manuscript File	71285_Auto_Edited.docx
Answering Reviewers	71285-Answering reviewers.pdf
Audio Core Tip	71285-Audio core tip.wav
Biostatistics Review Certificate	71285-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	71285-Conflict-of-interest statement.pdf
Copyright License Agreement	71285-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71285-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	71285-Institutional review board statement.pdf
Peer-review Report	71285-Peer-review(s).pdf
Scientific Misconduct Check	71285-Bing-Fan JR-2.png
Scientific Editor Work List	71285-Scientific editor work list.pdf