Publication Name	World Journal of Gastroenterology
Manuscript ID	7135
Country	Italy

Received	2013-11-05 22:28
Peer-Review Started	2013-11-06 16:01
First Decision by Editorial Office Director
Return for Revision	2014-02-11 09:43
Revised	2014-03-13 04:24
Publication Fee Transferred
Second Decision by Editor	2014-05-19 11:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-19 11:25
Articles in Press	2014-05-23 09:57
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 14:57
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance
Manuscript Source	Invited Manuscript
All Author List	Valentina Grossi, Alessia Peserico, Tugsan Tezil and Cristiano Simone
Funding Agency and Grant Number	Funding Agency Grant Number Italian Association for Cancer Research (AIRC) fellowship to Grossi V Italian Foundation for Cancer Research (FIRC) fellowships to Peserico A and Tezil T Italian Association for Cancer Research (AIRC) IG10177 (to Simone C) FIRB “Futuro in Ricerca” from the Italian MIUR RBFR12VP3Q_003 (to Simone C)
Corresponding Author	Cristiano Simone, MD, PhD, Division of Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, Via Nazionale 8/A, Bari 70124, Italy. simone@negrisud.it
Key Words	p38 mitogen-activated protein kinase; Chemoresistance; Molecularly-targeted drugs; Colorectal cancer; Cell death
Core Tip	The pro-apoptotic effects of p38α activation are long recognized; however, a significant number of reports describes the involvement of p38α in cancer-specific metabolism, survival, proliferation, and chemoresistance of colorectal cancer cells and tissues. p38α blockade exerts its chemosensitizing effects through nuclear accumulation of FoxO3A and activation of its pro-apoptotic gene expression program, thereby improving the efficacy of anti-cancer treatments. Apoptosis induction upon p38α inhibition requires Bax, which may thus serve as a predictive bio-marker for p38α-targeted therapy response. The novel role described for the p38-FoxO3A axis in chemoresistance might offer new options for combined therapies and personalized medicine approaches.
Publish Date	2014-08-07 10:34
Citation	Grossi V, Peserico A, Tezil T, Simone C. p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol 2014; 20(29): 9744-9758
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9744.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9744

Full Article (PDF)	WJG-20-9744.pdf
Full Article (Word)	WJG-20-9744.doc
Manuscript File	7135-Review.docx
Answering Reviewers	7135-Answering reviewers.pdf
Copyright License Agreement	7135-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	7135-Language certificate.pdf
Peer-review Report	7135-Peer review.pdf
Scientific Editor Work List	7135-Scientific editor work list.pdf